DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and CG10077

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001261491.1	Gene:	CG10077 / 38756	FlyBaseID:	FBgn0035720	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	907	Identity:	407/907 - (44%)
Similarity:	511/907 - (56%)	Gaps:	171/907 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 FGGAAGGAGINGAATAAGSMHFGQPYGVMTYGIQNGLGMGAAGSGGGN----------PYRQQNG 104
            |||..||    ||...||.|            :.|.:|.||.|.|.|.          ||...||
  Fly    11 FGGGGGG----GAGGLAGGM------------VPNRMGGGAPGGGPGGAGMFQRNRSAPYPGFNG 59

  Fly   105 VAFAGNGL----GGGAGGGSGG---SGGYGGQRGKNPTYAQRYQKPNNGAGVAGGYQSNNYNAAA 162
            ...|..|.    |||...|.||   ..|:|||.                    ||.:|:|:
  Fly    60 HGPANGGQRRMNGGGPSMGPGGPRNQDGFGGQN--------------------GGQRSSNH---- 100

  Fly   163 LGMLSKEERAEIQREKAKNPGRNLVKPKWE--NLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEI 225
                                |.:|.|..|.  ||.||.|:||....:.||::..:........||
  Fly   101 --------------------GAHLPKIVWSEVNLTPFRKNFYKPCDSVLARTVGETETFLTSNEI 145

  Fly   226 TVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLA 290
            |:.|:::|.|.:.|||...|.:|:.|:::|||.||||||:||||||:|||||||:||||||||||
  Fly   146 TIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVGVAQTGSGKTLA 210

  Fly   291 YMLPAIVHIGNQPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQ 355
            |:|||:|||.|||.:.||:||||||||||||||||||.|..::|  ....:|:||||||:.|..|
  Fly   211 YVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFG--SNTHVRNTCIFGGAPKGQQ 273

  Fly   356 ARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQV 420
            ||||:||||::||||||||||||...|:|:|||||||||||||||||||||||||::||||||||
  Fly   274 ARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMGFEPQIRKIMQQIRPDRQV 338

  Fly   421 VMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIK 485
            :||||||||||:.||.:|||:|||:||||::|||||||.|||::|.|.||..:|:.||.:|
  Fly   339 LMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIKLLTDI---- 399

  Fly   486 NSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDV 550
             |..|..|.|:|||||.:|::|.:.|..:|:.|.:|||||:|.|||.||..||||:.:||:||||
  Fly   400 -SAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSFRNGRHSILVATDV 463

  Fly   551 ASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQ 615
            |:|||||:|:::|||||||::||:||||||||||....|||||.||..||.:|.:||.||.||.|
  Fly   464 AARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLREANQ 528

  Fly   616 TPSQALLDLARSMPSSGGYRGNKRWNNNSGGDRNTGGNNGIYQQRNNNPL---NYQAGNNYNNNR 677
            |.:..|:::|    .:|||  |||.....||.|   |.|| ||.|  ||.   .|..||||.||
  Fly   529 TINPKLMNMA----MNGGY--NKRGGGMGGGYR---GGNG-YQGR--NPQMGGGYNGGNNYRNN- 580

  Fly   678 SGPPTGSSYQQYAAGGNTYLQNGAGGGVNWNRM------NQMGQ-----DGGAG-------QQQR 724
            :||  |::..:     |::....|||...:::.      ||.||     .||.|       |||:
  Fly   581 NGP--GATMNR-----NSFNGGSAGGPPRFDQKPRTSPPNQGGQGGYRGQGGGGYQGQQQQQQQQ 638

  Fly   725 NGNTYRPRAPFNNGGPRAIM---GHQGGGVGAGGAAGVGGGPQQLMAPQQGGQYMPQAY------ 780
            ||.     .||:...|.|..   .....|.|:|.........||..|.|| ...:|.|.
  Fly   639 NGG-----VPFSRFNPNAACFEPNKPQNGPGSGPPQAQHQQQQQAQAAQQ-QHLLPDASVQAAMT 697

  Fly   781 -------RGRSQFVPQGAGAGGMPP--RFQQYPKREYQQQGVTHYGQQALQHQQQQQQAGQQTKP 836
                   :.||:|.|.......|||  ..||......|||      ||.||..|||||..|..:|
  Fly   698 AANYGVDQKRSRFSPYNMNFANMPPPAMNQQQAAAAQQQQ------QQQLQTPQQQQQQQQMQQP 756

  Fly   837 PKDESNKYVPSAAVTSSLVQYTPANSPTIAAVAAAAAAAAGRAAAAAVAPAPGAAYMYDAAG 898
                 ..|...::::||:.        |::....|||.|:...|..|| |...|.||....|
  Fly   757 -----QAYGQYSSMSSSMA--------TVSLNGGAAAVASSYRAPYAV-PTQAAPYMMANGG 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	289/521 (55%)
		DEADc	239..446	CDD:238167	152/206 (74%)
		HELICc	457..594	CDD:238034	78/136 (57%)
CG10077	NP_001261491.1	PTZ00110	49..544	CDD:240273	297/551 (54%)
		DEADc	159..364	CDD:238167	152/206 (74%)
		HELICc	375..507	CDD:238034	78/136 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451415
Domainoid	1	1.000	255	1.000	Domainoid score	I1101
eggNOG	1	0.900	-	-		E2759_KOG0331
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	536	1.000	Inparanoid score	I268
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	1	1.000	-	-		mtm1005
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	P	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X504
	12	11.750