DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx50

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001013216.2	Gene:	Ddx50 / 361848	RGDID:	1310934	Length:	734	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	155/505 - (30%)
Similarity:	250/505 - (49%)	Gaps:	70/505 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EERAEIQREKAKNPGRNLVKPK------------WENLEPFLKDFYNIHPNTLAKSEQQ------ 215
            |||.| .||.......:..|||            .|.|. |..:|...|     ||.::
  Rat    42 EERTE-TRENGVTDDLDAPKPKKAKTREKLNGDTKEGLR-FSDEFSPSH-----KSRRKDLPNGD 99

  Fly   216 VAEIRRELEITVSGNELPHPVV--------------SFEESSLPAHVIEEMKRQGFTKPTAIQSQ 266
            |.|..:..: .||.:|..|...              :|...|:....|:.:|.:|.|....||.:
  Rat   100 VDEYEKRSK-RVSSSENSHKSSDKADETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVK 163

  Fly   267 GWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHI-GNQPPIIRGEGPIALVLAPTRELAQQIQSVV 330
            .:.....|:||:..|:||:|||.::.:|.|..: .||..|.:...|..||||||||||.|   |.
  Rat   164 TFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQ---VA 225

  Fly   331 RDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEA 395
            :|:..:.: ::...|.:||:|...|...:..|:::::.||||:.|.|::...:|.:..::||||.
  Rat   226 KDFKDITR-KLNVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEV 289

  Fly   396 DRMLDMGFEPQIRKII-EQIRPDR----QVVMWSATWPKEVQALAGDFLND-YIQIN-IGSMNLS 453
            |:|||:||..|:..|| |..:.|.    |.:::|||.|:.|..:|..::.. |.|:: :|.|...
  Rat   290 DQMLDLGFAEQVEDIIHESYKSDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQK 354

  Fly   454 ANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNA 518
            |...:..:...|...::|    .::.::..: .||:.| :.|:|.|||..|.::......: .||
  Rat   355 AATTVEHLAIQCHWSQRP----AVIGDVLQV-YSGSEG-RAIIFCETKKNVTEMAMNPHIK-QNA 412

  Fly   519 TSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTG 583
            ..:|||..|::|:..||.||.|...:|:||:||:||||:.::..||....|...|:|:||.||||
  Rat   413 QCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTG 477

  Fly   584 RCQQLGTAYTFFTPDNAKQARELISVLEEAGQT------PSQALLDLARS 627
            |..:.|....|:.|   ::..:|..|.::||.|      ||  .:||.:|
  Rat   478 RAGRTGICVCFYQP---RERGQLRYVEQKAGITFKRVGVPS--TMDLVKS 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	155/505 (31%)
		DEADc	239..446	CDD:238167	73/213 (34%)
		HELICc	457..594	CDD:238034	45/136 (33%)
Ddx50	NP_001013216.2	SrmB	130..608	CDD:223587	133/409 (33%)
		DEADc	136..339	CDD:238167	71/206 (34%)
		HELICc	369..486	CDD:238034	44/123 (36%)
		GUCT_RHII_Gualpha_beta	565..656	CDD:240593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820