DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and eIF4A

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	136/402 - (33%)
Similarity:	214/402 - (53%)	Gaps:	39/402 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 NELP-----------------HPVV-SFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRD 276
            ||:|                 |.|. :|::.:|...::..:...||.||:|||.:.....:.|||
  Fly     5 NEIPQDGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRD 69

  Fly   277 LVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEI 341
            ::..||:|:|||..:.:..:..|.......:     ||:||||||||.|||.||...|...|..
  Fly    70 VIAQAQSGTGKTATFSIAILQQIDTSIRECQ-----ALILAPTRELATQIQRVVMALGEYMKVH- 128

  Fly   342 RHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQ 406
            .|.|| ||::....||.|:.|..|::.||||:.|.:..:....|.....||||||.||..||:.|
  Fly   129 SHACI-GGTNVREDARILESGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQ 192

  Fly   407 IRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQI-VEICTEIEK 470
            |:.:.:.:.||.||::.|||.|.:|..::..|:.|.:.|.:....|:. ..|:|. |.:..|..|
  Fly   193 IQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTL-EGIKQFYVNVKQENWK 256

  Fly   471 PQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLK 535
            ...|..|.:.:|..::        ::|..|:.||:.:.|.:....:..:::|||..|.:|:.::|
  Fly   257 LGTLCDLYDTLSITQS--------VIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMK 313

  Fly   536 DFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNA 600
            .||:|.|.:||.||:.:||:||:.:..|||||.|::.|||:|||||.||..:.|.|..|.|.|:
  Fly   314 QFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDD- 377

  Fly   601 KQARELISVLEE 612
               |.::..:|:
  Fly   378 ---RRILKDIEQ 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	136/402 (34%)
		DEADc	239..446	CDD:238167	75/206 (36%)
		HELICc	457..594	CDD:238034	49/137 (36%)
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	135/401 (34%)
		DEADc	32..232	CDD:238167	75/206 (36%)
		Helicase_C	254..358	CDD:278689	38/111 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840