DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and CG6227

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	241/784 - (30%)
Similarity:	365/784 - (46%)	Gaps:	123/784 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 AAALGMLSKEERAEIQREKAKNPGRNLVKPKWENLEPFLKDFYNIHPNTLAKSEQQVAEIRRELE 224
            |..|.|..::|.|:|.....             ...||.|:||...|.....:...|.:.|.:||
  Fly   445 AVNLAMKHRKELAKIDHSSV-------------TYAPFRKNFYVEVPELTRMTAADVEKYRSDLE 496

  Fly   225 -ITVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKT 288
             |.|.|...|.|:.::.:..:....:|.::|.||.|||.||.|..|..:|||||:|||:||||||
  Fly   497 GIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKT 561

  Fly   289 LAYMLPAIVHIGNQPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKV 353
            ||::||...||.:||.:..|:|.||:::||||||..||...:|.:..  ...:|..|::||:...
  Fly   562 LAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSK--SLGLRPVCVYGGTGIS 624

  Fly   354 PQARDLDRGVEVIIATPGRLIDFL---ENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIR 415
            .|..:|.||.|:|:.||||:||.|   ..|.|||:|.||:||||||||.|||||||:.:||:.:|
  Fly   625 EQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVR 689

  Fly   416 PDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNE 480
            ||||.||:|||:|::::|||...|...|::.:|..::           :|.|:|:.   |.:||:
  Fly   690 PDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSV-----------VCKEVEQH---VVILND 740

  Fly   481 ------ISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRN 539
                  :..:.........|||||:.:...:.:|:.:....|...|:||...|.:|||.:.||::
  Fly   741 DAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKS 805

  Fly   540 GKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQAR 604
            ||..:||||.||:|||||:||..|:|||.||..|:||||.|||||..:.|:||||.||:.::.|.
  Fly   806 GKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAG 870

  Fly   605 ELISVLEEAGQ----------TPSQALLDL-ARSMPSSGGYRG---------------NKRWNNN 643
            ::|..::.:|.          |..:||.:. .:::.:.||:.|               :|:....
  Fly   871 DIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKA 935

  Fly   644 SGGDRNTGGNNGIYQQRNNNPLNYQAGNNYNNNRSGPPTGSSYQQYAAGGNTYLQNGAGGGVNWN 708
            :.|..::.....|.|..:.......|......:.|...|.::....||.......:||...
  Fly   936 ALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPA---- 996

  Fly   709 RMNQMGQDGGAGQQQRNGNTYRPRAPFNNGG-PRAIMG------------------HQGGGVGAG 754
             :........|.....|.......||...|| |...||                  :....:...
  Fly   997 -LASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLDTK 1060

  Fly   755 GAA----------GVGGGPQQLMAPQQGGQYMPQAYRGRSQFVP----QGAG--AGGMPPRFQQY 803
            |:.          .|.|....|:..:...:.|......:..:.|    :|.|  .||....|.:|
  Fly  1061 GSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKEDEEGLGPLVGGTTNPFTKY 1125

  Fly   804 PK----REYQQQG---VTHYGQQALQHQQQQQQAG---------QQTKPPKDESNKYVPSAAVTS 852
            .:    .::.||.   ||  .::||....:..:||         |...||..|...|:...:.:.
  Fly  1126 EEELEINDFPQQARWKVT--SKEALAQISEYSEAGLTVRGTYVPQGKNPPDGERKLYLAIESCSE 1188

  Fly   853 SLVQ 856
            ..||
  Fly  1189 LAVQ 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	196/531 (37%)
		DEADc	239..446	CDD:238167	103/209 (49%)
		HELICc	457..594	CDD:238034	56/142 (39%)
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	187/500 (37%)
		DEADc	516..719	CDD:238167	103/204 (50%)
		HELICc	733..860	CDD:238034	53/129 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451468
Domainoid	1	1.000	152	1.000	Domainoid score	I185
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9750
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850