DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx41

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001101516.1	Gene:	Ddx41 / 314336	RGDID:	1311758	Length:	622	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	190/518 - (36%)
Similarity:	273/518 - (52%)	Gaps:	49/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 GYQSNNYNAAALGMLSK----EERAEIQREKAKN--------------PGRNLVK----PKWENL 194
            |.|||      :.:|.:    :|:||.::|.||.              .||.|:.    .|....
  Rat    80 GPQSN------VSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITY 138

  Fly   195 EPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTK 259
            :..:|..:......|:.||::...:|::..|.|.|:.:|.|:.||:|..|||.::..:|::|...
  Rat   139 DDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILH 203

  Fly   260 PTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQP---PIIRGEGPIALVLAPTRE 321
            ||.||.||.|..|||||::|||.|||||||.:.||.|:....|.   |..:.|||..|::.|:||
  Rat   204 PTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRE 268

  Fly   322 LAQQIQSVVRDYGHLCK----PEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNT 382
            ||:|...::..|..|.:    |.:|.....||.|...|...:..||.:::||||||:|.|:.:..
  Rat   269 LARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMV 333

  Fly   383 NLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINI 447
            :|..|.||.|||||||:|||||..||.|....:..||.:::|||.||::|..|...|...:.||:
  Rat   334 SLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINV 398

  Fly   448 GSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIR 512
            |....::...|:::..:..|.:....|.||.....|          :::|.|.|..|:.|.:.:.
  Rat   399 GRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPP----------VLIFAEKKADVDAIHEYLL 453

  Fly   513 AEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVH 577
            .:|..|.:|||.|.|.||...::.||.||.::|:||||||:|||...:|:|||||.|...|||||
  Rat   454 LKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVH 518

  Fly   578 RIGRTGRCQQLGTAYTFFTPD-NAKQARELISVLEEAGQTPSQALLDL---ARSMPSSGGYRG 636
            |||||||....|.|.||.... :.....:|.::|.||.|.....|..|   ..||...||.||
  Rat   519 RIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	190/518 (37%)
		DEADc	239..446	CDD:238167	91/213 (43%)
		HELICc	457..594	CDD:238034	55/136 (40%)
Ddx41	NP_001101516.1	DEADc	183..397	CDD:238167	91/213 (43%)
		DEXDc	196..409	CDD:214692	89/212 (42%)
		Helicase_C	418..527	CDD:278689	52/118 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930