DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and dbp3

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_596388.1	Gene:	dbp3 / 2540213	PomBaseID:	SPBC17D1.06	Length:	578	Species:	Schizosaccharomyces pombe

Alignment Length:	487	Identity:	188/487 - (38%)
Similarity:	264/487 - (54%)	Gaps:	54/487 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 SKEERAEIQRE---KAKNPGRNLVKPKWENLEPFLKDFYNIHPNTLA--KSEQQVAEIRRELEIT 226
            :|||..||..|   |...|..........|.|.....:...|..:.|  ||.:.:.
pombe   109 TKEESIEINAEEGAKIAQPAIGSANASNHNDEEAYDRYIKKHNISFADPKSSENLL--------- 164

  Fly   227 VSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAY 291
                    |::.|:|..:.|.:.|.:|  .:.:||.||:..||..|:|||:||||:||||||:|:
pombe   165 --------PILQFDELDVSAKLREGLK--NYKEPTPIQAATWPYLLAGRDVVGIAETGSGKTVAF 219

  Fly   292 MLPAIVHIGNQPPIIRGEGPIALVLAPTRELA----QQIQSVVRDYGHLCKPEIRHTCIFGGSSK 352
            .:||:.::.....  ....|..||::||||||    :.:.|:::.      ..::...::||:.|
pombe   220 GIPALQYLNGLSD--NKSVPRVLVVSPTRELAIQTYENLNSLIQG------TNLKAVVVYGGAPK 276

  Fly   353 VPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPD 417
            ..||| ..:...|||.|||||:|.:.:.:.:..:..||||||||||||.|||..||.||.. .||
pombe   277 SEQAR-AAKNASVIIGTPGRLLDLINDGSIDCSQVGYLVLDEADRMLDTGFEQDIRNIISH-TPD 339

  Fly   418 ------RQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVC 476
                  ||.|.:|||||:.|:|||..||.|.::|.|||..|:|:.||.|||||..:....:|:
pombe   340 PTRNGSRQTVFFSATWPESVRALAATFLKDPVKITIGSDELAASQNITQIVEILDDPRSKERM-- 402

  Fly   477 LLNEISPIKNSGNNGNKIIVFVETK---IKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFR 538
            |.|.:....:||...:||::||..|   .:||..|    |..||...||||.:|..|...|.||:
pombe   403 LDNLLRKHLSSGGKDDKILIFVLYKKEAARVEGTL----ARKYNVVGIHGDMSQGARLQALNDFK 463

  Fly   539 NGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQA 603
            :||..:|:|||||:||||:..:|.|||..:|.:.|:||||||||||....|||.|||||.:...|
pombe   464 SGKCPVLVATDVAARGLDIPKVQLVINVTFPLTIEDYVHRIGRTGRANTKGTAITFFTPQDKSHA 528

  Fly   604 RELISVLEEAGQTPSQALLDLARSM-PSSGGY 634
            .||::||.:|.|...:.|.....:: |....|
pombe   529 GELVNVLRQAKQDIPEGLFKFGTAVKPKLNAY 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	188/487 (39%)
		DEADc	239..446	CDD:238167	89/216 (41%)
		HELICc	457..594	CDD:238034	63/139 (45%)
dbp3	NP_596388.1	PTZ00424	169..549	CDD:185609	171/397 (43%)
		DEADc	169..374	CDD:238167	89/216 (41%)
		HELICc	385..519	CDD:238034	63/139 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770