DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and Ddx46

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001268984.1	Gene:	Ddx46 / 212880	MGIID:	1920895	Length:	1032	Species:	Mus musculus

Alignment Length:	808	Identity:	245/808 - (30%)
Similarity:	387/808 - (47%)	Gaps:	123/808 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 GGYGGQRGKNPTYAQRYQKPNNGAGVA------GGYQSNNYNAAALGMLSKEERAEIQREKA--K 180
            ||.|.::...||..:..........|.      |....|:.:  |:...|:||..::|....  :
Mouse   249 GGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQD--AMEYSSEEEEVDLQTALTGYQ 311

  Fly   181 NPGRNLVKP----KWENLEPFLKDFYNIHPNTLAKSEQQVAEIRRELE-ITVSGNELPHPVVSFE 240
            ...|.|::|    |.| .|||.|:||...|.....|:::|...|.|:| |||.|...|.|:.|:.
Mouse   312 TKQRKLLEPVDHGKIE-YEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWV 375

  Fly   241 ESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPI 305
            :..:...::..:|:.|:.|||.||:|..|..:|||||:|||:||||||:|::||...||.:|..:
Mouse   376 QCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSL 440

  Fly   306 IRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATP 370
            ..||||||:::.||||||.||....:.:....  .:|..|::||:....|..:|.||.|:|:.||
Mouse   441 EEGEGPIAVIMTPTRELALQITKECKKFSKTL--GLRVVCVYGGTGISEQIAELKRGAEIIVCTP 503

  Fly   371 GRLIDFL---ENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQ 432
            ||:||.|   ..|.|||:|.||:||||||||.|||||||:.:|::.:|||||.||:|||:|:.::
Mouse   504 GRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAME 568

  Fly   433 ALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVF 497
            |||...|:..|::.:|..::..:...:|::    .||:.::.:.||..:...:.||:    :|:|
Mouse   569 ALARRILSKPIEVQVGGRSVVCSDVEQQVI----VIEEEKKFLKLLELLGHYQESGS----VIIF 625

  Fly   498 VETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQY 562
            |:.:...:.:|:.:....|...|:||...|.:|||::.||:||...:|:||.||:|||||:.|..
Mouse   626 VDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLIL 690

  Fly   563 VINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDL--- 624
            |:||..||..|:||||.|||||....|.||||.|.|.|:.|.::|..||.:|......|..|
Mouse   691 VVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSD 755

  Fly   625 --------ARSMPSSGGYRG---------------NKRWNNNSGGDRNTGGNNGIYQQRNNNPLN 666
                    .:.:..|.|:.|               .|:....:.|.:::...:....      ::
Mouse   756 FKDQQKAEGKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDDEDAAVD------ID 814

  Fly   667 YQAGNNYNNNR----SGPPTGSSYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQQQRNGN 727
            .|..:.:|:.:    ...|..||.....||....|:......:..|....:|.:......|:..|
Mouse   815 EQIESMFNSKKRVKDMAAPGTSSVPAPTAGNAEKLEIAKRLALRINAQKNLGIESQVDVMQQATN 879

  Fly   728 TYRPRAPFNNGGPRAIMGHQGGGVGAGGAAGVGGGPQQLMAPQQG----GQYMPQAYRGRSQFVP 788
                          ||:  :||               .::||...    .:.:.:....:..:||
Mouse   880 --------------AIL--RGG---------------TILAPTVSAKTIAEQLAEKINAKLNYVP 913

  Fly   789 -----QGAGAGGMPPRFQQYPK----REYQQQG---VTHYGQQALQHQQQQQQAG--------QQ 833
                 :....||....|::|.:    .::.|..   ||  .::|||...:..:|.        ..
Mouse   914 LEKQEEERQEGGQSESFKRYEEELEINDFPQTARWKVT--SKEALQRISEYSEAAITIRGTYFPP 976

  Fly   834 TKPPKDESNK-YVPSAAVTSSLVQYTPA 860
            .|.||:...| |:...:.....||...|
Mouse   977 GKEPKEGERKIYLAIESANELAVQKAKA 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	201/561 (36%)
		DEADc	239..446	CDD:238167	99/209 (47%)
		HELICc	457..594	CDD:238034	52/136 (38%)
Ddx46	NP_001268984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..227
		SrmB	344..826	CDD:223587	183/497 (37%)
		Q motif	372..400		7/27 (26%)
		DEADc	378..581	CDD:238167	99/204 (49%)
		DEAD box	529..532		2/2 (100%)
		Helicase_C	618..714	CDD:278689	44/99 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920