DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and glh-4

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_491207.3	Gene:	glh-4 / 171941	WormBaseID:	WBGene00001601	Length:	1156	Species:	Caenorhabditis elegans

Alignment Length:	798	Identity:	205/798 - (25%)
Similarity:	332/798 - (41%)	Gaps:	191/798 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FAGAYAPNAGGVQQHTGGGYYGNGAAAGAGG------SGNGAPRHERQYYPRGNFGGAAGGAGIN 60
            |.||..|..|| ...||   :|:|..||.||      ..:|.|....      .|||....||.
Worm   409 FGGASKPGFGG-DSSTG---FGSGLKAGFGGHRASTAENSGLPTETT------GFGGKLPPAGF- 462

  Fly    61 GAATAAGSMHFGQP---YGVMTYGIQNGLG------MGAAGSGGGNPYRQQNG--VAFAGNGL-- 112
             .|:::....|||.   :|..|   :||.|      .|...||.|.|..|..|  .|.:.:||
Worm   463 -GASSSNESAFGQQSKGFGGAT---KNGFGGDSSNSFGKRDSGFGGPQDQGFGDTDAPSKSGLGS 523

  Fly   113 ---GGGAGGGSGGSGGYGGQR--GKNPTYAQRYQKPNNGAGVAGGYQSNN-YNAAALGMLSKE-E 170
               ||||...:.|:.|:|...  |...|:.:  ...|......||.:... :|....|.:||| :
Worm   524 FNTGGGAVKSAFGAAGFGSSSNFGNGNTFGE--PSDNQRGNWDGGERPRGCHNCGEEGHISKECD 586

  Fly   171 RAEIQREKAKN-------------------PGRN----------LVKPK---------------- 190
            :.::.|...:|                   |.||          ..:||
Worm   587 KPKVPRFPCRNCEQLGHFASDCDQPRVPRGPCRNCGIEGHFAVDCDQPKVPRGPCRNCGQEGHFA 651

  Fly   191 ---------WENLEP------------------------FLK--DFYNIHPNTL---AKSEQQVA 217
                     .|..||                        ||:  ||.....:.:   |.:.....
Worm   652 KDCQNERVRMEPTEPCRRCAEEGHWGYECPTRPKDLQGNFLESYDFVFTPDDKMFEDAVNNDDKI 716

  Fly   218 EIRRELEITVSGNELPHPVVSFEE-SSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIA 281
            :..:::..:....|:| .:.||:. ..||..:.:.:||....:||.||...:...:.|.|:|..|
Worm   717 DFDQKVVASTGKVEIP-DMASFDGFKILPQDLHDNLKRMKMNRPTPIQRASFFPIMHGNDVVACA 780

  Fly   282 QTGSGKTLAYMLPAIV----------HIGNQPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHL 336
            .||||||||:::|.::          .:.::.|     .|..|::||||||..|..:..|...:
Worm   781 HTGSGKTLAFLIPFVIKLMEEFEKDRDVTDEKP-----SPRLLIVAPTRELVNQTFTTARQLTY- 839

  Fly   337 CKPEIRHTCIFGGSSK---VPQARDLDRGVEVIIATPGRLIDFLENRNTNLQRCTYLVLDEADRM 398
             :..::....|||.|:   |...|...: :.:::||.|||.||:.....:|.:..|:||||||||
Worm   840 -ETGLKCGLAFGGYSRNANVQHLRSFSQ-LNILVATMGRLQDFVNAGEVSLSKMKYIVLDEADRM 902

  Fly   399 LDMG-FEPQIRKII----EQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNL----SA 454
            :|.. |..::.|||    |:   .:|.|::||::.:::|:   |.|..:::.....:.:    :|
Worm   903 VDSNDFGEEVSKIIGSPGER---TQQTVLFSASFSEDLQS---DDLPKFVKEGYTMLQVDKFGTA 961

  Fly   455 NHNIRQIVEICTEIEKPQRLVCLL----NEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEG 515
            |..|.|.:......||...:..||    |.::.:.::.....|.::||.:....:.:..:|.:.|
Worm   962 NEKIDQKILPVPRTEKRDAIYKLLGIDENTVTLLPDAPIEKQKTLIFVNSVKFCDTLAALISSAG 1026

  Fly   516 YNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYP--NSSENYVHR 578
            .:..|:|..:.|.:||..|.|||.||...::|::|.:|||::..|.:|:|||.|  |..:.||:|
Worm  1027 VSTISMHSYQNQEQRDRTLDDFRRGKYQCMVASNVCARGLNIAGLDHVVNYDMPDKNGFDEYVNR 1091

  Fly   579 IGRTGRCQQLGTAYTFFTPDNAKQARE-LISVLEEAGQTPSQALLDLARSMPSSGGYRGNKRWNN 642
            ||||||....||:..|...:|...... |:|:|.||           .:.:|         .|..
Worm  1092 IGRTGRAGFTGTSTAFVDVENDTDIIPCLVSILNEA-----------KKEVP---------EWLT 1136

  Fly   643 NSGGDRNTGGNNGIYQQR 660
            ...|.:..||::...|::
Worm  1137 EGAGHQEEGGDDWNEQEQ 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	155/634 (24%)
		DEADc	239..446	CDD:238167	69/225 (31%)
		HELICc	457..594	CDD:238034	46/142 (32%)
glh-4	NP_491207.3	zf-CCHC	570..587	CDD:278525	5/16 (31%)
		PTZ00368	572..685	CDD:173561	15/112 (13%)
		zf-CCHC	616..633	CDD:278525	3/16 (19%)
		zf-CCHC	639..656	CDD:278525	0/16 (0%)
		P-loop_NTPase	743..938	CDD:304359	65/205 (32%)
		DEXDc	751..968	CDD:214692	69/230 (30%)
		HELICc	964..1104	CDD:238034	45/139 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910