DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and DDX5

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001307524.1	Gene:	DDX5 / 1655	HGNCID:	2746	Length:	614	Species:	Homo sapiens

Alignment Length:	631	Identity:	319/631 - (50%)
Similarity:	404/631 - (64%)	Gaps:	86/631 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GYGGQRGKNPTYAQRYQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPGRNLVKP 189
            ||...|.:               |...|:.:..:..:..|.||        .:|..|||..|||.
Human     3 GYSSDRDR---------------GRDRGFGAPRFGGSRAGPLS--------GKKFGNPGEKLVKK 44

  Fly   190 KW--ENLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLPAHVIEEM 252
            ||  :.|..|.|:||..||:...::.|:|...||..||||.|:..|.||::|.|::.||:|::.:
Human    45 KWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVI 109

  Fly   253 KRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEGPIALVLA 317
            .||.||:|||||:||||:||||.|:||:|||||||||:|:|||||||.:||.:.||:|||.||||
Human   110 ARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLA 174

  Fly   318 PTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLIDFLENRNT 382
            ||||||||:|.|..:|...|:  ::.|||:||:.|.||.|||:||||:.||||||||||||...|
Human   175 PTRELAQQVQQVAAEYCRACR--LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKT 237

  Fly   383 NLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINI 447
            ||:|.|||||||||||||||||||||||::|||||||.:||||||||||:.||.|||.|||.|||
Human   238 NLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 302

  Fly   448 GSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIR 512
            |::.|||||||.|||::|.::||.::|:.|:.||...|.     ||.|||||||.:.:::.:.:|
Human   303 GALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKE-----NKTIVFVETKRRCDELTRKMR 362

  Fly   513 AEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVH 577
            .:|:.|..|||||:|.|||.||.:|::||:.||||||||||||||||:::|||||||||||:|:|
Human   363 RDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIH 427

  Fly   578 RIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLARSMPSS-----GG---- 633
            |||||.|..:.|||||||||:|.||..:|||||.||.|..:..||.|.....|.     ||
Human   428 RIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDD 492

  Fly   634 ----YRGNKRWNNNSGGDRNT-------------GG--NNGIYQQRNNNPLNYQAGNNY------ 673
                |...||...|:..||..             |.  .||:|...|..  |...|:|:
Human   493 RRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYT--NGSFGSNFVSAGIQ 555

  Fly   674 NNNRSGPPTGS------SYQQYAAGGNT-YLQNGAGGGVNWNRMNQ 712
            .:.|:|.|||:      |.|||  |.|. .:.||         |||
Human   556 TSFRTGNPTGTYQNGYDSTQQY--GSNVPNMHNG---------MNQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	294/549 (54%)
		DEADc	239..446	CDD:238167	144/206 (70%)
		HELICc	457..594	CDD:238034	78/136 (57%)
DDX5	NP_001307524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		11/58 (19%)
		PTZ00110	6..507	CDD:240273	290/530 (55%)
		Q motif	94..122		13/27 (48%)
		DEAD box	248..251		2/2 (100%)
		Transactivation domain	477..614		33/127 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..504		6/26 (23%)
		P68HR	498..532	CDD:400414	6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10660
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.680