DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and DDX17

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001091974.1	Gene:	DDX17 / 10521	HGNCID:	2740	Length:	731	Species:	Homo sapiens

Alignment Length:	712	Identity:	338/712 - (47%)
Similarity:	424/712 - (59%)	Gaps:	95/712 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 GSGGSGGYGGQRGKNPTYAQRYQKPNNGAGVAGGYQSNNYNAAALGMLSKEERAEIQREKAKNPG 183
            |:...||: |.|.::        :...|.|..||                   ..:..:|..|||
Human    78 GTMRGGGF-GDRDRD--------RDRGGFGARGG-------------------GGLPPKKFGNPG 114

  Fly   184 RNLVKPKWE--NLEPFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNEL-PHPVVSFEESSLP 245
            ..|.|.||:  .|..|.|:||..||.....:..:|.|:||:.||||.|.:: |.||.:|..::.|
Human   115 ERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFP 179

  Fly   246 AHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG 310
            .:|::.:..|.||:||.||.||:|:||||||:||||||||||||||:|||||||.:||.:.||:|
Human   180 QYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDG 244

  Fly   311 PIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLID 375
            ||.||||||||||||:|.|..|||...:  ::.|||:||:.|.||.|||:||||:.|||||||||
Human   245 PICLVLAPTRELAQQVQQVADDYGKCSR--LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLID 307

  Fly   376 FLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLN 440
            |||:..|||:|||||||||||||||||||||||||::|||||||.:||||||||||:.||.|||.
Human   308 FLESGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLR 372

  Fly   441 DYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVE 505
            ||.|||:|::.|||||||.|||::|.|.||..:|:.|:.||...|.     ||.|:|||||.:.:
Human   373 DYTQINVGNLELSANHNILQIVDVCMESEKDHKLIQLMEEIMAEKE-----NKTIIFVETKRRCD 432

  Fly   506 DILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPN 570
            |:.:.:|.:|:.|..|||||:|.|||.||.:||:||:.||||||||||||||||:::||||||||
Human   433 DLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPN 497

  Fly   571 SSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLA--RSMPSSGG 633
            |||:||||||||.|....|||||||||.|.|||||||.|||||.|..:..|:.|.  |.....||
Human   498 SSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGG 562

  Fly   634 YRGNKRWNNNSGG-----------DRNTGG-------NNGIYQQRN-NNPLNYQAGNNYNNNRSG 679
            ..|..|:...|..           ||...|       ::..|:.|: .:...|..|:.|.:..|.
Human   563 KGGRSRYRTTSSANNPNLMYQDECDRRLRGVKDGGRRDSASYRDRSETDRAGYANGSGYGSPNSA 627

  Fly   680 PPTGSSYQQYAAGGNTYLQNGAGGGVNWNRMNQMGQDGGAGQQQRNGNTYRPRAPFNNGGPRAIM 744
              .|:...||..|..||      |...:...:...|:.|||       ||...:..:.|......
Human   628 --FGAQAGQYTYGQGTY------GAAAYGTSSYTAQEYGAG-------TYGASSTTSTGRSSQSS 677

  Fly   745 GHQGGGVGAGGAAGVGGGPQQLMAPQQGGQYMPQAYRGRSQFVPQGAG--AGGMPPRFQQYP 804
            ..|..|:|..|..     ||.||: ||..|             |.||.  .|.|.....|||
Human   678 SQQFSGIGRSGQQ-----PQPLMS-QQFAQ-------------PPGATNMIGYMGQTAYQYP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	294/542 (54%)
		DEADc	239..446	CDD:238167	144/206 (70%)
		HELICc	457..594	CDD:238034	81/136 (60%)
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..115		12/64 (19%)
		Q motif	171..199		9/27 (33%)
		DEADc	173..378	CDD:238167	144/206 (70%)
		DEXDc	191..393	CDD:214692	150/203 (74%)
		DEAD box	325..328		2/2 (100%)
		HELICc	389..521	CDD:238034	81/136 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..731		22/79 (28%)
		Interaction with YAP1. /evidence=ECO:0000269\|PubMed:24581491	720..728		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9578
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S387
OMA	1	1.010	-	-		QHG53695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000439
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100364
Panther	1	1.100	-	-	O	PTHR47958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730