DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and Ddx55

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001258255.1	Gene:	Ddx55 / 100362764	RGDID:	2324094	Length:	600	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	132/409 - (32%)
Similarity:	201/409 - (49%)	Gaps:	71/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 SFEESSLPAH--VIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIG 300
            |:|...:|.|  |:..::..||...|.:||...|:.:..:|:...|.||||||||:::| |:.|
  Rat     8 SWESLQVPLHPLVLGALRELGFLHMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIP-ILEI- 70

  Fly   301 NQPPIIRGEGPI------ALVLAPTRELAQQIQSVVRDYGHLCK--PEIRHTCIFGGSSKVPQAR 357
                ::|.|..:      |:|:.||||||.||..|:   .|..|  |:.......||.:   ...
  Rat    71 ----LLRREEKLKKNQVGAIVITPTRELAIQIDEVL---SHFTKHFPQFSQILWIGGRN---PGE 125

  Fly   358 DLDR----GVEVIIATPGRLIDFLENRNTNLQRCTY------LVLDEADRMLDMGFEPQIRKIIE 412
            |::|    |..:|:||||||.|....:...|...:|      ||||||||:||||||..|..|:|
  Rat   126 DVERFKQHGGNIIVATPGRLEDMFRRKAEGLDLASYVKSLDVLVLDEADRLLDMGFEASINTILE 190

  Fly   413 QIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSA-----------NHNIRQIVEICT 466
            .:...|:..::|||..:||:.|....|.:.::|::....::|           ||.:     ||.
  Rat   191 FLPKQRRTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYM-----ICK 250

  Fly   467 EIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRA--EGYNATSIHGDKTQNE 529
            ..||..:||..|.        .....|.:||..|...||...:.:.|  :......||| |.:.:
  Rat   251 ADEKFNQLVHFLR--------SRQQEKHLVFFSTCACVEYYGKALEALVQRVKILCIHG-KMKYK 306

  Fly   530 RDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTF 594
            |:.:..:||..:|.||:.|||.:||:|:.::.:|:.||.|:::..:|||.|||.|....|:|..|
  Rat   307 RNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVF 371

  Fly   595 FTPDNAKQARELISVLEEA 613
            ..|            :|||
  Rat   372 LLP------------MEEA 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	132/409 (32%)
		DEADc	239..446	CDD:238167	79/226 (35%)
		HELICc	457..594	CDD:238034	43/138 (31%)
Ddx55	NP_001258255.1	DEADc	9..224	CDD:238167	79/226 (35%)
		DEXDc	24..228	CDD:214692	76/215 (35%)
		Helicase_C	252..363	CDD:278689	39/119 (33%)
		DUF4217	403..462	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0331
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810