DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahe and ddx46

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_002935944.1	Gene:	ddx46 / 100145307	XenbaseID:	XB-GENE-5787809	Length:	1049	Species:	Xenopus tropicalis

Alignment Length:	798	Identity:	251/798 - (31%)
Similarity:	372/798 - (46%)	Gaps:	165/798 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 ALGMLSKEERAEIQREKA--KNPGRNLVKP----KWENLEPFLKDFYNIHPNTLAKSEQQVAEIR 220
            |:...|:||..::|....  :...|.|::|    |.| .|.:.|:||...|.....:.::|...|
Frog   290 AMEYSSEEEEVDLQTALTGFQTKQRKLLEPVDHGKIE-YESYRKNFYVEVPELAKMTTEEVNSYR 353

  Fly   221 RELE-ITVSGNELPHPVVSFEESSLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTG 284
            .||| |||.|...|.|:.|:.:..:...::..:|:..:.|||.||:|..|..:|||||:|||:||
Frog   354 LELEGITVKGKNCPKPIKSWVQCGISMKILNSLKKHAYEKPTPIQAQAIPAIMSGRDLIGIAKTG 418

  Fly   285 SGKTLAYMLPAIVHIGNQPPIIRGEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGG 349
            ||||:|::||...||.:|.|:..||||||:::.||||||.||....:.:....  .:|..|::||
Frog   419 SGKTIAFLLPMFRHIMDQRPLEEGEGPIAVIMTPTRELALQITKECKKFSKTL--GLRVVCVYGG 481

  Fly   350 SSKVPQARDLDRGVEVIIATPGRLIDFLENRN---TNLQRCTYLVLDEADRMLDMGFEPQIRKII 411
            :....|..:|.||.|:|:.||||:||.|...|   |||:|.||:||||||||.|||||||:.:||
Frog   482 TGISEQIAELKRGAEIIVCTPGRMIDMLAANNGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRII 546

  Fly   412 EQIRPDRQVVMWSATWPKEVQALAGDFLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVC 476
            :.||||||.||:|||:|:.::|||...|:..|::.:|..::..: ::.|.|.:   ||:.::.:.
Frog   547 DNIRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCS-DVEQHVIV---IEEEKKFLK 607

  Fly   477 LLNEISPIKNSGNNGNKIIVFVETKIKVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGK 541
            ||..:...:..|    .:|:||:.:...:.:|:.:....|...|:||...|.:|||::.||:||.
Frog   608 LLELLGHYQEKG----AVIIFVDKQEHADGLLKDLMRASYPCLSLHGGIDQYDRDSIINDFKNGV 668

  Fly   542 SNILIATDVASRGLDVEDLQYVINYDYPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQAREL 606
            ..:|:||.||:|||||:.|..||||..||..|:||||.|||||....|.|:||.|.|.|:.|.::
Frog   669 CKLLVATSVAARGLDVKQLILVINYACPNHYEDYVHRAGRTGRAGNKGYAFTFITEDQARYAGDI 733

  Fly   607 ISVLEEAGQTPSQALLDLARSMPSSGGYRGNKRWN-----NNSGGD--RNTGGNNGIYQQRNNNP 664
            |..||.:|......|..|               ||     ..:.|.  :.|.|.:|
Frog   734 IKALELSGTAVPAELEQL---------------WNEFKEQQKAEGKIIKKTSGFSG--------- 774

  Fly   665 LNYQAGNNYNNNRSGPPTGSSYQQYAAGGNTYLQNGAGGGV-------------NWNRMNQMGQD 716
                .|..::.............|.||.|   ||:......             :..|:..|...
Frog   775 ----KGFKFDETEQALANERKKLQKAALG---LQDSDDEDTALDIDEQIESMFNSKKRVKDMAGP 832

  Fly   717 GGAGQQQRNGNTYRPRAPFNNGGPRAIMGHQGGGVGAGGAA------------------------ 757
            |||..               .|.|    |..||.||||.:|
Frog   833 GGAAA---------------TGAP----GMVGGAVGAGSSANATLPTAGNAEKLEIAKRLAKKLS 878

  Fly   758 ---GVGGGPQQLM-----APQQGG-------------QYMPQAYRGRSQFVP--------QGAGA 793
               .:|...|.:|     |..:||             :.:.:....:..:||        |.|||
Frog   879 VNKNLGAEAQDVMQQATNAILRGGTILAPTVSAKTIAEQLAEKINAKLNYVPVEKLEEEKQDAGA 943

  Fly   794 GGMPPRFQQYPK----REYQQQG---VTHYGQQALQHQQQQQQA-----GQQTKPPKD----ESN 842
            .   ..|::|.:    .::.|..   ||  .::|||...:..:|     |....|.||    |..
Frog   944 N---ESFKRYEEELEINDFPQTARWKVT--SKEALQRISEYSEAAITIRGTYFPPGKDPKEGERK 1003

  Fly   843 KYVPSAAVTSSLVQYTPA 860
            .|:...:.:...||...|
Frog  1004 IYLAIESASELAVQKAKA 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	198/510 (39%)
		DEADc	239..446	CDD:238167	101/209 (48%)
		HELICc	457..594	CDD:238034	52/136 (38%)
ddx46	XP_002935944.1	DEADc_DDX46	360..581	CDD:350711	107/222 (48%)
ddx46	XP_002935944.1	SrmB	367..825	CDD:223587	182/498 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010