DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mahe and ddx42

DIOPT Version :9

Sequence 1:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_002935570.1	Gene:	ddx42 / 100135374	XenbaseID:	XB-GENE-972670	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	761	Identity:	240/761 - (31%)
Similarity:	367/761 - (48%)	Gaps:	105/761 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QRYQKPNNGAGVAGG------------YQSNNYNAAALGMLSKEERAEIQREKAKNPGRNLVK-- 188
            :|.::..|..|:...            |.:.|..|   |::.:||...::.:...||.....|
Frog   133 ERDKEKKNARGIRDDIEEEDDQEAYFRYMAENPTA---GLVPEEEEDNLEYDSDGNPIAPTTKRI 194

  Fly   189 ----PKWENLE----PFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEESSLP 245
                |..::.|    ||.|:||..|....:::.||:.|:|.:|.:.|||...|....||......
Frog   195 IDPLPPIDHTEIEYTPFEKNFYEEHEEITSQTPQQITELRHKLNLRVSGAAPPRLCSSFAHFGFD 259

  Fly   246 AHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIRGEG 310
            ..::.::::..:|:||.||.||.|:||||||::|||:||||||.|::.|.:|||.:|..:..|:|
Frog   260 EQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPILVHIMDQKELQPGDG 324

  Fly   311 PIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGRLID 375
            |||:::.|||||.|||.|..:.:|...  .:|...::||.|...||:.|..|.|:::.|||||||
Frog   325 PIAVIVCPTRELCQQIHSECKRFGKAY--NLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLID 387

  Fly   376 FLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGDFLN 440
            .::.:.|||||.||||.||||||.|||||.|:|.|...:|||||.:::|||:.|:::.||.|.|.
Frog   388 HVKKKATNLQRVTYLVFDEADRMFDMGFEYQVRSIANHVRPDRQTLLFSATFRKKIEKLARDILV 452

  Fly   441 DYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKIKVE 505
            |.|::..|.:. .||.:|.|:|||..  ..|::...|...:....::|:    :::||..|...|
Frog   453 DPIRVVQGDIG-EANEDITQVVEILP--SGPEKWTWLTRRLVEFTSTGS----VLIFVTKKANAE 510

  Fly   506 DILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYDYPN 570
            ::...:|.:.:....:|||..|:||:.|:.||:.....:|:|||||:||||:..::.|||||...
Frog   511 ELANNLRQDDHPLGLLHGDMDQSERNKVISDFKKKSIPVLVATDVAARGLDIPSIKTVINYDVAR 575

  Fly   571 SSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLARSMPSSGGYR 635
            ..:.:.||||||||..:.|.|:|..||.::..|.:|:..||.|.|..|:.|||||  |.:|  :.
Frog   576 DIDTHTHRIGRTGRAGEKGVAHTLLTPKDSNFAGDLVRNLEGANQYVSKELLDLA--MQNS--WF 636

  Fly   636 GNKRWNNNSGGDRNTGGNNGIYQQRNNNPLNYQAGNNYNNNRSGPPTGSSYQQYAAGGN---TYL 697
            ...|:....|...|.||....|::|                   |..|:.......|||   .|.
Frog   637 RKSRFKAGKGKKLNIGGGGLGYRER-------------------PGLGAETSDRGVGGNVMSNYE 682

  Fly   698 QNGAGGGVNWNRMNQMGQDGGAGQQQRNGNTYRPRAPFNNGGPRAIMGHQGGGVGAGGAAGV-GG 761
            .....||...:|::.|   ..|.|.|...:.....|.....|..:|  :.|....||..:.| ..
Frog   683 AFKPTGGAMGDRLSAM---KAAFQSQYKNHFVAASASTQKTGTSSI--NSGAWTSAGSLSSVPSA 742

  Fly   762 GPQQLMAPQQGG-----------------QYMPQAYRGRSQF---------VPQGAGAG---GMP 797
            .|..:..|.:..                 ..:|..|...|..         ...||.||   |..
Frog   743 HPPSVKLPAEAAPPPVHTTMLGFTSSGTLSSIPTGYPNISNASYPAATLFGARDGASAGSESGSK 807

  Fly   798 PRF----------QQYPKREYQQQGVTHYGQQALQHQQQQQQAGQQ 833
            .|.          .::..||..:.|..|....:.:|.::....|::
Frog   808 ERHSDSRGRHGDSHRHGDREGHRHGDGHRHSSSSRHGERNGGEGRR 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	201/539 (37%)
		DEADc	239..446	CDD:238167	99/206 (48%)
		HELICc	457..594	CDD:238034	47/136 (35%)
ddx42	XP_002935570.1	PTZ00110	196..650	CDD:240273	186/466 (40%)
ddx42	XP_002935570.1	PRK12678	733..>940	CDD:237171	20/121 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920