DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hdm and Meiob

DIOPT Version :9

Sequence 1:	NP_572422.1	Gene:	hdm / 31705	FlyBaseID:	FBgn0029977	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001108505.1	Gene:	Meiob / 685099	RGDID:	1583204	Length:	470	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	133/498 - (26%)
Similarity:	224/498 - (44%)	Gaps:	75/498 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FQRLAEMRPTMTRFSTVALIVSKSSPNIFYDKMS-GTERGVLSLTIRDSPNHLTNCKCWGQRDCV 70
            |..|:::.|.|.....:.:::.|:....|.|:.: |:||...|.||||||||..|...||..|.:
  Rat    10 FTALSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPNHFVNVSSWGSEDYI 74

  Fly    71 DEYAAMLQIGHVVDIVGAKVMSIPFAAPGEQRYQPQATVSCALVVNEGSGYV---VRHDNDDFGQ 132
            ...:...::|..|.|....:..  .....|:|:.|....:..|:::|....|   ..::.|
  Rat    75 RSLSDNFKVGECVIIENPLIQR--KETEREERFSPATPSNYKLLLSENHSMVKVCSPYEVD---- 133

  Fly   133 ITILQQLLHQPIRPLGAVLKLAD-VRSGLGFPDKIITTNVNLLVVVAAVRPVRQIK-------RK 189
             |.|..|:|.|::.......||| |.:|.....:||.       |:||||.|.:.|       ||
  Rat   134 -TKLLSLIHLPVKESRDYYSLADIVANGHSLDGRIIN-------VLAAVRSVGEPKYFTTSDRRK 190

  Fly   190 LQGPLSEVQELLQCLEVIVIDASYPEGMLLSVWQPDWIQRAQQWQPRRTVLHLIDVRVSYSNFHR 254
            .|          :| ||.:.|.:.| ...::.|..:.|..||.|..|.||:...|||::::.|..
  Rat   191 GQ----------RC-EVKLFDETEP-SFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQN 243

  Fly   255 SLVLSHSNCTLICENPQAAGDDCRLLLAFAATVPLTTFSGCDQAELD-------NMPAVASIQAQ 312
            .:..:..:.|:|..||..  .:..:||.|......|:.:.    |:|       |:..:.::
  Rat   244 CMAATVISKTIITVNPDT--PEANILLNFIRENKETSIAD----EIDSYLKESVNLNTIVNV--- 299

  Fly   313 MTVRQIYSRA---EGELQDPSIHQFTAVLYGMVTKFDLDGLTSHVNR-KCIACQQHIPRNLQDCA 373
            .||.|:..:|   ||:: ||    |..:||..::..::|..|:.|.| :|.:|..     :.:.|
  Rat   300 YTVEQLKGKALENEGKV-DP----FYGILYAYISTLNIDDETTKVVRNRCSSCGY-----IVNDA 354

  Fly   374 SDACQQYFSLDNDEPRSISY---FNINIHLSDQTGTLVEARLAGHPAERILGLRAEDFERLAERE 435
            |:.|.   ....|..||.|:   |::.:.|:|.||||....|:|..||..||....:|..:...:
  Rat   355 SNTCT---ICSKDSSRSRSFCLSFDVLVDLTDHTGTLRSCSLSGSVAEETLGCTINEFLTMTSEQ 416

  Fly   436 KSELKWRFLLKYFEVRLMIKKPVGVRNHLVIVVVDMQ-AIPLE 477
            |::|||:.||:..::.|.:......|..|.:.::..: |.|:|
  Rat   417 KTKLKWQLLLERSKIYLKLILSHRARGGLKVTILSCKLADPIE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hdm	NP_572422.1	None
Meiob	NP_001108505.1	rpa1	<165..408	CDD:273177	77/283 (27%)
Meiob	NP_001108505.1	RPA1_DBD_B	167..270	CDD:239921	35/123 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340858
Domainoid	1	1.000	140	1.000	Domainoid score	I4628
eggNOG	1	0.900	-	-		E1_COG1599
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H102013
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4406
OMA	1	1.010	-	-		QHG47556
OrthoDB	1	1.010	-	-		D277291at33208
OrthoFinder	1	1.000	-	-		FOG0006958
OrthoInspector	1	1.000	-	-		oto97983
orthoMCL	1	0.900	-	-		OOG6_107559
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.670