DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hdm and meiob

DIOPT Version :9

Sequence 1:	NP_572422.1	Gene:	hdm / 31705	FlyBaseID:	FBgn0029977	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_021328187.1	Gene:	meiob / 101882335	ZFINID:	ZDB-GENE-120104-8	Length:	466	Species:	Danio rerio

Alignment Length:	491	Identity:	133/491 - (27%)
Similarity:	221/491 - (45%)	Gaps:	67/491 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAEMRPTMTRFSTVALIVSKSSPNIFYDKMS-GTERGVLSLTIRDSPNHLTNCKCWGQRDCVDEY 73
            ::::...:|....|.:|:.|:....|.|:.: |:||...|.||:|||.|..|...||..:.:...
Zfish    12 ISDLNINITHSKVVGVIIGKTDSRGFPDRKNVGSERFTFSFTIKDSPEHFINVSAWGNEEYIQAL 76

  Fly    74 AAMLQIGHVVDIVGAKVMSIPFAAPGEQRYQPQATVSCALVVNE-GSGYVVRHDNDDFGQITILQ 137
            :...|||..|.|....|::..:..  |:|:.|....|..|::.| .|...:..|.|...:|.
Zfish    77 SCRFQIGDCVVIENPLVVTKDYEK--EERFCPSTPSSYRLLLTETHSSIRICSDIDTEARIL--- 136

  Fly   138 QLLHQPIRPLGAVLKLADV-RSGLGFPDKIITTNVNLLVVVAAVRPVRQIK--RKLQGPLSEVQE 199
            .|.|.||:.......|.|: .:|......:|.       ::|||:.|.:.|  .|..|...
Zfish   137 PLFHIPIKDPRDFYSLGDITANGQSLDGHVIN-------ILAAVQSVGEEKFFTKSGGCKG---- 190

  Fly   200 LLQCLEVIVID---ASYPEGMLLSVWQPDWIQRAQQWQPRRTVLHLIDVRVSYSNFHRSLVLSHS 261
              |.:|:.:.|   .|:|    ...|..:.|:..|....|.|||.:.|.|:::.:|.:|:|.:..
Zfish   191 --QRIEIKLFDDTGRSFP----FVCWDKENIRLVQTLTQRETVLFIADARITFDSFRKSMVATAI 249

  Fly   262 NCTLICENPQAAGDDCRLLLAFAATVPLTTFSGCDQAEL---DNMPAVASIQAQMTVRQIYSRAE 323
            :.|:|..||..|  :...|..|..  .|....|.|..:.   |:: .:.||:..|||.|:.:|::
Zfish   250 SKTIITVNPDTA--EANQLYTFVR--ELLQSGGLDDQDFLSGDDV-LLDSIRDVMTVSQLKTRSQ 309

  Fly   324 GELQDPSIHQFTAVLYGMVTKFDLDGLTSH-VNRKCIACQQHIPRNLQDCASDACQQYFSLDNDE 387
             |..| :||   .::||.:|.|||....|. :.::|..|:..|......|:||.|..    ...|
Zfish   310 -ENAD-AIH---CIIYGFITCFDLGSSPSKIITKRCARCKFRINEESWTCSSDICPN----QGQE 365

  Fly   388 PRSISYFNINIHLSDQTGTLVEARLAGHPAERILGLRAEDFERLAEREKSELKWRFLLKYFEVRL 452
            .::...|::.:.:||.||||....|.|..||:.||.:.|:|..|:|.:::.|:|:|||:..::.|
Zfish   366 LQANECFDVLVDISDHTGTLQSCNLVGTVAEKTLGCKTEEFLCLSEYQRTSLQWKFLLERCKIYL 430

  Fly   453 MI-------------------KKPVGVRNHLVIVVV 469
            .:                   ..||.|:.:|...||
Zfish   431 KVLPSPRRRSGMKADILSCGLADPVEVKQNLASFVV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hdm	NP_572422.1	None
meiob	XP_021328187.1	RFA1	<112..427	CDD:333227	97/348 (28%)
meiob	XP_021328187.1	RPA_2b-aaRSs_OBF_like	166..266	CDD:324543	30/118 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580709
Domainoid	1	1.000	141	1.000	Domainoid score	I4669
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H102013
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4469
OMA	1	1.010	-	-		QHG47556
OrthoDB	1	1.010	-	-		D277291at33208
OrthoFinder	1	1.000	-	-		FOG0006958
OrthoInspector	1	1.000	-	-		otm25734
orthoMCL	1	0.900	-	-		OOG6_107559
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.810