DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and SNX29

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_011521040.1	Gene:	SNX29 / 92017	HGNCID:	30542	Length:	879	Species:	Homo sapiens

Alignment Length:	831	Identity:	160/831 - (19%)
Similarity:	271/831 - (32%)	Gaps:	259/831 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 VRQLTMAKGECEKNLAKFGWNGNYSSDIDLTLVEILNTAVGRRYFTLFLEPLKASALIGFYLAVE 452
            :.:|..|..:|:   .:||.....:||.|..:     |.:..::..:....||.|.  |..|...
Human    24 LERLLDAVKQCQ---IRFGGRKEIASDSDSRV-----TCLCAQFEAVLQHGLKRSR--GLALTAA 78

  Fly   453 EIKHAHKSASHQLGTEIFYTYIRVPKSEIQIDKHERKLIETFLLGDAEPDIFYDIQ--------- 508
            .||.|...||......:|:.|::    |: ::|||.:.             ||.::
Human    79 AIKQAAGFASKTETEPVFWYYVK----EV-LNKHELQR-------------FYSLRHIASDVGRG 125

  Fly   509 ----RNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPGAADG 569
                |..|.....:.|...:|:|:.|.      |....|.:.:|       .|..:...|..|.|
Human   126 RAWLRCALNEHSLERYLHMLLADRCRL------STFYEDWSFVM-------DEERSSMLPTMAAG 177

  Fly   570 LNGGAGGAI---------DVAAHTSYA-------RRKLEQIQERIDKKNQALDALKYSVKPESKV 618
            ||     :|         |:...:.:|       :...:.:...:.:..|.:.:|...:...|.|
Human   178 LN-----SILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREITASSAV 237

  Fly   619 LTIL--EKEMEWLKSEKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEKESLQFMILVHVDEDI 681
            ..::  |:|.:.|....|...|     ||..:...|.|..:.::...|::|          ||..
Human   238 SILIKPEQETDPLPVVSRNVSA-----DAKCKKERKKKKKVTNIISFDDEE----------DEQN 287

  Fly   682 NAPV-------QPTSSKNGDSGHANLR---KRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKA 736
            :..|       ..:|..|.|....|:.   :.|.|.:|.                 ...|||...
Human   288 SGDVFKKTPGAGESSEDNSDRSSVNIMSAFESPFGPNSN-----------------GSQSSNSWK 335

  Fly   737 ID-LPTNFKFFFLKTD-------------------------RHGQEKAKSQIQKFLNFILEDDHL 775
            || |..|.:|.:.|.|                         |...|..:..::.  |..|...|.
Human   336 IDSLSLNGEFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKPLEG--NTCLSQMHS 398

  Fly   776 --------NGSEAIYTF-----LSPS-------------SDHLKQSLPSPKKSKFS--------- 805
                    |.|:.::..     .||:             .||:   ||.| ..::|
Human   399 WAPLKVLHNDSDILFPVSGVGSYSPADAPLGSLENGTGPEDHV---LPDP-GLRYSVEASSPGHG 459

  Fly   806 --LSTLFRS----DAGKAHEASKATDPFWG----LQRDDEDISTYLDGESGGEAKMLAADLDS-K 859
              ||:|..|    ::....|..:||.....    |:.::..:...||||....| .|..::|: |
Human   460 SPLSSLLPSASVPESMTISELRQATVAMMNRKDELEEENRSLRNLLDGEMEHSA-ALRQEVDTLK 523

  Fly   860 DSIAE-------PMYALMGEIFDMGGVFKWLRKSLISFVQ--------------------ITYGR 897
            ..:||       .:.||..|    ..|.|...|..:..||                    :|...
Human   524 RKVAEQEERQGMKVQALARE----NEVLKVQLKKYVGAVQMLKREGQTAEVPNLWSVDGEVTVAE 584

  Fly   898 TINRQIRESVAYLFEESMLH---------NYFSAILKSFWPGGVLASAYPTRSEDMR-----EMT 948
            ....:|.|.:|..:|..::.         .:...:.::......|.|.......|:|     :::
Human   585 QKPGEIAEELASSYERKLIEVAEMHGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLS 649

  Fly   949 TTAA-----------KALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILM 1002
            .|:.           :||:...||.|.  |.|..|....|.:|:..:::..:|....|.....|.
Human   650 QTSEDQSLSDFEISNRALINVWIPSVF--LRGKAANAFHVYQVYIRIKDDEWNIYRRYTEFRSLH 712

  Fly  1003 IEFFPEIRQLRVSNSNGTKL--NTATAGAAAASAAAALVAATASASLPSLN 1051
            .:...:..|:|..|....|.  |......|..:|||:|:|:...| ||.||
Human   713 HKLQNKYPQVRAYNFPPKKAIGNKPPPSPAWMTAAASLLASLLPA-LPPLN 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373
		RGS_SNX25	422..531	CDD:188675	24/121 (20%)
		PX_SNX25	645..788	CDD:132788	33/191 (17%)
		Nexin_C	882..987	CDD:285792	23/149 (15%)
SNX29	XP_011521040.1	RUN	54..189	CDD:280855	34/172 (20%)
		Ax_dynein_light	<487..552	CDD:287215	16/69 (23%)
		PX_RUN	668..820	CDD:132810	27/98 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900