DRSC/TRiP Functional Genomics Resources

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Protein Alignment snz and SNX27

DIOPT Version :9

Sequence 1:NP_001284993.1 Gene:snz / 31704 FlyBaseID:FBgn0029976 Length:1117 Species:Drosophila melanogaster
Sequence 2:NP_001317652.1 Gene:SNX27 / 81609 HGNCID:20073 Length:541 Species:Homo sapiens


Alignment Length:336 Identity:71/336 - (21%)
Similarity:125/336 - (37%) Gaps:65/336 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 SGNLEELSLIRKSIVNDLMHATTMQNLQRAKGLDPDHEDHSLSKSELTAAVR-LKRYVRQLTMAK 395
            |....|.:::.:::..:..:.|    ..|..|..|    .|||:.:|.|..| |:.|:.::...:
Human   194 SKRYREFAILHQNLKREFANFT----FPRLPGKWP----FSLSEQQLDARRRGLEEYLEKVCSIR 250

  Fly   396 --GE---CEKNLAKFGWNGNYSSDIDL-------TLVEI---LNTAVGRRYFTLFLEPLKASALI 445
              ||   .::.|::...|.|..||::|       |.|.:   .|:...:.|..:..:....|..:
Human   251 VIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTV 315

  Fly   446 GFYLAVEEIKHA--HKSASHQLGTEIF---YTYIRVPKSEIQIDKHERKLIETFLLGDAEPDIFY 505
            .::...|.|.|:  .|.|.::...:::   || ..||.:.:.|.|......|..||.|.:..:.|
Human   316 NYFALFEVISHSFVRKLAPNEFPHKLYIQNYT-SAVPGTCLTIRKWLFTTEEEILLNDNDLAVTY 379

  Fly   506 -------DIQRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQ 563
                   |:::..::. |||.|.   |...|.|.|..:..|     .|..|....::..|..   
Human   380 FFHQAVDDVKKGYIKA-EEKSYQ---LQKLYEQRKMVMYLN-----MLRTCEGYNEIIFPHC--- 432

  Fly   564 PGAADGLNGGAGGAIDVAAHTSYARRKLEQIQERIDKKNQAL-----DALKYSVKPESKVLTIL- 622
              |.|....|     .|....|....||....|....:||.:     :..::....|....... 
Human   433 --ACDSRRKG-----HVITAISITHFKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEY 490

  Fly   623 ---EKEMEWLK 630
               ||:..|:|
Human   491 ARGEKKPRWVK 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snzNP_001284993.1 PXA 142..299 CDD:280373
RGS_SNX25 422..531 CDD:188675 26/123 (21%)
PX_SNX25 645..788 CDD:132788
Nexin_C 882..987 CDD:285792
SNX27NP_001317652.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
PDZ_signaling 41..133 CDD:238492
PX_SNX27 160..265 CDD:132796 17/78 (22%)
FERM_F1_SNX27 273..365 CDD:340475 19/92 (21%)
FERM-like region F1 273..362 19/89 (21%)
FERM-like region F2 373..421 12/56 (21%)
FERM-like_C_SNX27 425..526 CDD:270146 16/87 (18%)
FERM-like region F3 425..525 16/87 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1370
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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