DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snz and Snx15

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_081188.1	Gene:	Snx15 / 69024	MGIID:	1916274	Length:	337	Species:	Mus musculus

Alignment Length:	383	Identity:	68/383 - (17%)
Similarity:	126/383 - (32%)	Gaps:	117/383 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 HLRRTDAWTEHLG--KWKATIQSVEVSDEKESLQFMILVHVDEDINAPVQPTSSKNGDSG--HAN 699
            |...:|..|...|  ::|.|.|.:...|.::..:.::.....:        ....:||..  |.|
Mouse    12 HYTVSDPRTHPKGYTEYKVTAQFISKKDPEDIKEVVVWKRYSD--------FRKLHGDLAYTHRN 68

  Fly   700 LRKR----PSGISSGWVVMRSLNQVHELQRK----LRHVSSNLKAIDLPTNFKFFFLKTDRHGQE 756
            |.:|    |: .....|..|....|.|.:||    |...:..:.|::.....|.||    |.|:.
Mouse    69 LFRRLEEFPA-FPRAQVFGRFEASVIEERRKGAEDLLRFTVPIPALNNSPQLKEFF----RGGEV 128

  Fly   757 KAKSQIQKFLNFILEDDHLNGSEAIYTFLSPSSDHLKQSLPSPKK----------------SKFS 805
            ...|::.:.|..:        ...:.....|....|.|.||:.::                ::.:
Mouse   129 TRPSEVSRDLRIL--------PPPLIPTPPPDEARLLQPLPAERRGQEELEVPVDPLPSSPAQEA 185

  Fly   806 LSTLFRSDAGKAHEASKATDPFWGLQRDDEDIS---TYLDGESGGEA-----KMLAADLDSK--- 859
            |..||..|:.:...:|.|..|.     .:.:::   .|...||.|.:     ::.|.:::||
Mouse   186 LDLLFSCDSTEEASSSLARGPL-----SEAELALFDPYSKEESTGPSPTHTGELAAIEVESKRLD 245

  Fly   860 -------------DSIAEPMYALMGEIFDMGGVFKWLRKSLISFVQITYGRTINRQIRESVAYLF 911
                         ....||..|.:|:..::                      |.:.:|...|
Mouse   246 QEPWEPGGQEEEEAEDGEPAPAYLGQATEL----------------------ITQALRNEKA--- 285

  Fly   912 EESMLHNYFSAILKSFWPG------GVLASAYPTRSEDMREMTTTAAK--ALLTDHIP 961
                  ..::|.|:.:..|      ||.....|.|.|.:::......|  .:|..|:|
Mouse   286 ------GAYAAALQGYQDGVHILLQGVSGDPSPARREGVKKKAAEYLKRAEMLHTHLP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373
		RGS_SNX25	422..531	CDD:188675
		PX_SNX25	645..788	CDD:132788	28/154 (18%)
		Nexin_C	882..987	CDD:285792	15/88 (17%)
Snx15	NP_081188.1	PX_domain	9..126	CDD:383026	27/126 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..156		2/30 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..270		3/25 (12%)
		MIT_SNX15	267..337	CDD:239140	16/100 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900