Protein Alignment snz and SNX14

DIOPT Version :9

• Sequence 1: NP_001284993.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_001337461.1
• Gene: SNX14 / 57231
• HGNCID: 14977
• Length: 967
• Species: Homo sapiens
• Alignment Length: 1158
• Identity: 230/1158 - (19%)
• Similarity: 397/1158 - (34%)
• Gaps: 384/1158 - (33%)

  Fly    14 RRLPLFPIEPEPSVTATQRLTLLATRLLRALQLN--------WRIIVSGITLTLLAVIW---YYP 67
            |:.|||         ....|.|.|..||    ||        |..|.||      .::|   |..
Human    26 RQYPLF---------CFLLLCLSAASLL----LNRLTEVPPWWCWIKSG------RILWITRYIH 71

  Fly    68 TFFLFFAFVVYSLVLVFAAVAGTVYIHYIFTTNEPTPPS-----------------------RVP 109
            ...:|::||. .:|..:.::.....:..||.|.:..|..                       ..|
Human    72 ILMIFWSFVA-GVVTFYCSLGPDSLLPNIFFTIKYKPKQLGLQELFPQGHSCAVCGKVKCKRHRP 135

  Fly   110 SRLLYNATKSNIFDLPKPIKNPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLIND 174
            |.||.|.         :|.     |.|.....||..|.:::|.||.:|:.||...|......:::
Human   136 SLLLENY---------QPW-----LDLKISSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDE 186

  Fly   175 V---VREDLWNAIQKIHERALRMDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSY 236
            :   :|......|::||    ::|...||...::.....|:|.|..|..:...|......:...|
Human   187 LRITLRFFASVLIRRIH----KVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEFLQQAALEEY 247

  Fly   237 -------LADEEKEMEFLRKLCEIMVILLLPRGYSLPP-------LKVLLSEILSYKIFFPMIKM 287
                   |.....|:.:||||.|    ||.|  |.|||       |.:|:.||||..:|.|.:..
Human   248 GPELHVALRSRRDELHYLRKLTE----LLFP--YILPPKATDCRSLTLLIREILSGSVFLPSLDF 306

  Fly   288 LTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASFEDFLKIINNSGNLEELSLIRKSIVNDLMHA 352
            |..||.:|..::..|:.     :..:::.|.|:....||:
Human   307 LADPDTVNHLLIIFIDD-----SPPEKATEPASPLVPFLQ------------------------- 341

  Fly   353 TTMQNLQRAKGLDPDHEDHSLSKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDIDL 417
                     |..:|.::..|:.|.||       :.:|:                     ..|:
Human   342 ---------KFAEPRNKKPSVLKLEL-------KQIRE---------------------QQDL-- 367

  Fly   418 TLVEILNTAVGRRYFTLFLEPLKASALIGFYLAVEEIKHAHKSASHQLGTEIFYTYIRVPKSEIQ 482
             |...:|          ||:...|..::.|.|.|||...                  |:.:.|:.
Human   368 -LFRFMN----------FLKQEGAVHVLQFCLTVEEFND------------------RILRPELS 403

  Fly   483 IDK----HE--RKLIETFLLGDA------EPDIFYDIQR-----------------------NVL 512
            .|:    ||  :|:.:|:.|.::      :|.|..:|||                       :||
Human   404 NDEMLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVL 468

  Fly   513 RTLEEKYYPPFVLSDQY-RQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPGAADGLNGGAGG 576
            ..||..:.|.|..||:| |||....:|                         |.....||.|
Human   469 SLLENVFTPMFCHSDEYFRQLLRGAES-------------------------PTRNSKLNRG--- 505

  Fly   577 AIDVAAHTSYARRKLEQIQER-----IDKKNQALDALKYSVKPESKVLT---ILEKEMEWLK--- 630
                    |.:.......|:|     |.:....:..:..|...|..:|.   :.|.|.::::
Human   506 --------SLSLDDFRNTQKRGESFGISRIGSKIKGVFKSTTMEGAMLPNYGVAEGEDDFIEEGI 562

  Fly   631 ---SEKRQTEAHLRRTDAWTEHLGKWKATIQSVEV-----SDEKESLQFMILVHVDEDINAPVQP 687
               .:....||  ..|.....:|..||.:|..|:.     |:.||..:.:.:..:|.:
Human   563 VVMEDDSPVEA--VSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVE------- 618

  Fly   688 TSSKNGDSGHANLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPT-------NFKF 745
                      .|.|:........|.|.|...:.:.|:.||...........||:       |::
Human   619 ----------RNDRRAVGHEPEHWSVYRRYLEFYVLESKLTEFHGAFPDAQLPSKRIIGPKNYE- 672

  Fly   746 FFLKTDRHGQEKAKSQIQKFLNFILEDDHLNGSEAIYTFLSPS---SDHLKQSLPSPKKSKFSLS 807
             |||:.|       .:.|::|..:|:...|:.|:.:..||||:   :..|.:.||.     .:|.
Human   673 -FLKSKR-------EEFQEYLQKLLQHPELSNSQLLADFLSPNGGETQFLDKILPD-----VNLG 724

  Fly   808 TLFRSDAGK-AHEASKATDPFWGLQRDDEDISTYLDGESGGEAKMLAADLDSKDSIAEPMYALMG 871
            .:.:|..|| ..|..:..:||         |..:::.....:.|....:|......:|....|..
Human   725 KIIKSVPGKLMKEKGQHLEPF---------IMNFINSCESPKPKPSRPELTILSPTSENNKKLFN 780

  Fly   872 EIF-----------------------DMGGVF--------------KWLRKSLISFVQITYGRTI 899
            ::|                       .:.||:              .||...|:. .:|.:..|:
Human   781 DLFKNNANRAENTERKQNQNYFMEVMTVEGVYDYLMYVGRVVFQVPDWLHHLLMG-TRILFKNTL 844

  Fly   900 ----NRQIRESVAYLFEESMLHNYFSAILKSFWPGGVLASAYPTRSEDMREMTTTAAKALLTDHI 960
                :..::..:..||:|..|.:..:.:..:.:    ..:..|...:|.::......:.:: ::|
Human   845 EMYTDYYLQCKLEQLFQEHRLVSLITLLRDAIF----CENTEPRSLQDKQKGAKQTFEEMM-NYI 904

  Fly   961 PEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILMIEFFPEIRQLR 1013
            |::|...:|.:.....:..:||.||.|..||||.|.||:|::.|.|||:.:::
Human   905 PDLLVKCIGEETKYESIRLLFDGLQQPVLNKQLTYVLLDIVIQELFPELNKVQ 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	49/173 (28%)
		RGS_SNX25	422..531	CDD:188675	31/144 (22%)
		PX_SNX25	645..788	CDD:132788	32/154 (21%)
		Nexin_C	882..987	CDD:285792	19/108 (18%)
SNX14	NP_001337461.1	PXA	151..320	CDD:308031	49/178 (28%)
		RGS_SNX14	361..487	CDD:188677	34/177 (19%)
		PX_SNX14	585..707	CDD:132787	31/147 (21%)
		Nexin_C	828..932	CDD:312222	19/109 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840