DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snz and snx27a

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001038565.1	Gene:	snx27a / 566205	ZFINID:	ZDB-GENE-060503-371	Length:	567	Species:	Danio rerio

Alignment Length:	323	Identity:	52/323 - (16%)
Similarity:	100/323 - (30%)	Gaps:	113/323 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 IAVDMVNRVTVHLEKI---------------RIAEARAAETNTPPVFSTNSY----------LAD 239
            |:|.....|..|.||.               |..|......|....||..::          |::
Zfish   168 ISVPTYKHVEQHSEKFVVYNVYMSGRQLCSKRYREFAILHQNLKREFSNYTFPKLPGKWPFSLSE 232

  Fly   240 EEKEM------EFLRKLCEIMVI--------------------------LLLP------------ 260
            ::.:.      |::.::|.:.:|                          :.||
Zfish   233 QQLDARRRGLEEYMERVCSVRIIGESDIMQEFLSESNENHNGITDVELRIALPDKTTASVRVQKN 297

  Fly   261 ----RGYSLPPLKVLLSEIL-SYKIFFPMI-----KMLTAPDYINQKVVQNIETRLAAAAMSKRS 315
                :.|....:||.:..:: ||...|.:|     :.|...::.::..|||..:.:....::.|.
Zfish   298 STTDQVYQALVVKVGMDSMMASYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTMRK 362

  Fly   316 YEYAASFED-----------------------FLKIINNSGNLEELSLIRKSIVNDLMHATTMQN 357
            :.::...||                       |:|..:.:..|::|:..||.       .|.:..
Zfish   363 WLFSTQEEDLLRDNPLALHYCFHQAQDDVKKGFIKAEDKAYQLQKLAEQRKM-------TTYLSL 420

  Fly   358 LQRAKGLD----PDHEDHSLSKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDID 416
            |:..:|.:    |.....|..|..:..||.:|.:........|..|..:..|.|:.....|.|
Zfish   421 LRSCEGYNEVTFPHCPCDSRRKGHVITAVSMKHFKLHACTEDGTLENQVIMFEWSEMQRWDTD 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	25/177 (14%)
		RGS_SNX25	422..531	CDD:188675
		PX_SNX25	645..788	CDD:132788
		Nexin_C	882..987	CDD:285792
snx27a	NP_001038565.1	PDZ_signaling	44..136	CDD:238492
		PX_SNX27	163..268	CDD:132796	15/99 (15%)
		SNX27_RA	277..363	CDD:176372	14/85 (16%)
		FERM-like_C_SNX27	428..529	CDD:270146	12/56 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030