Protein Alignment snz and KIF16B

DIOPT Version :10

• Sequence 1: NP_572421.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_005260807.1
• Gene: KIF16B / 55614
• HGNCID: 15869
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 212/1165 - (18%)
• Similarity: 366/1165 - (31%)
• Gaps: 412/1165 - (35%)

  Fly   112 LLYNATKSNIFDLPKPIKNPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVV 176
            :|||   ..:|    |||.|..|.|.|.:....:|:::                .:|.|||.::
Human   590 MLYN---PGLF----PIKGPICLRLEFERQQREELEKL----------------ESKRKLIEEM- 630

  Fly   177 REDLWNAIQKIHERALRMDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADEE 241
                        |...:.|.|:             ||::                         :
Human   631 ------------EEKQKSDKAE-------------LERM-------------------------Q 645

  Fly   242 KEMEFLRKLCEIMVILLLPRGYSLP----PLKVLLSEILSYKIFFPMIKMLTAPDYINQKVVQNI 302
            :|:|..||..||:.:.:..:..||.    .::..|.::|:.|..|...::....:...||..|..
Human   646 QEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEE 710

  Fly   303 ETRLAAAAMSKRSYEYAASFEDFLKIINNSGNLEELSLIRKSIVNDLMHATTMQNLQRAKGLDPD 367
            ||.|......:|           ||.:||:...|:..:.::           :..||:.|
Human   711 ETFLRVQEELQR-----------LKELNNNEKAEKFQIFQE-----------LDQLQKEK----- 748

  Fly   368 HEDHSLSKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDIDLTLVEILNTAVGRRYF 432
              |...:|.||... ||:...::..|.....|:.|.:           ...::::|     ||..
Human   749 --DEQYAKLELEKK-RLEEQEKEQVMLVAHLEEQLRE-----------KQEMIQLL-----RRGE 794

  Fly   433 TLFLEPLKASALIGFYLAVEEIKHAHKSASHQLGTEI------FYTYIR---------------- 475
            ..::|..|.. |.|...::..:|.| ::...:.|.|:      |:.:.|
Human   795 VQWVEEEKRD-LEGIRESLLRVKEA-RAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQ 857

  Fly   476 --VPKSEIQ-------------------IDKHERKLIET--------------FLLGDAEPDIFY 505
              :.|.|:|                   ::||:..:.:.              :.|...|..:.|
Human   858 KDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQY 922

  Fly   506 DIQRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIA-DPTLLMCH-TIGDVQEPLADEQPGA-- 566
            .:|.::...||||           ::..|.||...:: |.||.... .:.:.:|.||..|..|
Human   923 LLQNHLPTLLEEK-----------QRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQ 976

  Fly   567 ADGLNGGAGGAIDVAAHTSYARRKLEQIQE---------------RIDKKNQAL----------- 605
            ...|........::|......|:|.::|.|               |:::::.||
Human   977 LQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIE 1041

  Fly   606 ----------------DALKYSVKPESKVLTILEKEMEWLKSEKRQTEAHLRRTD-AWTEHLG-- 651
                            ..|:.|::.|.:.   |||:.|.|:.|.:|.:..:...| ...:|.|
Human  1042 EQRQKLASLNSGSREQSGLQASLEAEQEA---LEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTL 1103

  Fly   652 KWKATIQSVEVSDEKESLQFMILVHVDEDINAPVQPTSSKNGDSGHANLRKRPSGISSGWVVMRS 716
            :.|....|:.||.||..|    :..:|..|||.::....:.....|   |....|.|:....|:.
Human  1104 EGKVASSSLPVSAEKSHL----VPLMDARINAYIEEEVQRRLQDLH---RVISEGCSTSADTMKD 1161

  Fly   717 LNQVHE--LQRKLRHVSSNLKAIDLPTNFKFFFLKTDRHGQEKAKSQIQKFLNFILEDDHLNGSE 779
            ..::|.  :||||::.....    .|..:....|..|   .....|.|::....:.::||.
Human  1162 NEKLHNGTIQRKLKYEKRQF----CPAWYLDPLLPRD---ATDTSSLIKEERREVDQNDHW---- 1215

  Fly   780 AIYTFLSPSSDH-LKQSLPSPKKSKFSLSTLFRSDAGKAHEASKATDPFWGLQRDDEDISTYLDG 843
                      || :..|:..||       |...:...:.|:           |||...:.....
Human  1216 ----------DHPMLWSVSGPK-------TTSSASQERTHQ-----------QRDQSSVPEVFQ- 1251

  Fly   844 ESGGEAKMLAADLDSKDSIAEPMYALMGEIFDMGGVF--KWLRKSLISFVQITYGRTINRQIRES 906
                         ||::....|.:|         |.|  |......|||  :....|.:.:..:|
Human  1252 -------------DSENKYGHPEHA---------GHFEPKCFNLPKISF--LNESNTDDAEDFQS 1292

  Fly   907 VAYLFEESMLHNYFSAI-LKSFWPGGVLASAYPTRSEDMREMTTTAAKALLTDHIPEVLCNLVGA 970
            .:..|.|.|.|.....: :||.|                         .||.....||..|..|.
Human  1293 QSENFSELMTHKDKHGLRVKSSW-------------------------TLLQHTSQEVSINSGGK 1332

  Fly   971 QAAKRGVLKVF-----------------DALQNPAYNKQLFYELLEILMIEFFPEIRQLRVSNSN 1018
            ||.:..||.:.                 ..|.:..|::|...|.|:...:.....:..:|...:|
Human  1333 QARQGKVLCLVLSEGISHEERASCSAPQSVLASEFYSEQQGEEELDAKKMSSSESLVNIRTEGNN 1397

  Fly  1019 G--------------TKLNTATAGAAAASAAAAL-----------VAATASASLPSLNH------ 1052
            |              |..:...||....|.|..:           ...|...|||.|.|
Human  1398 GLGYFYHKFSDLYKDTSSHLLQAGTKVISQARLVGNLCAPRGLPSQVTTFVRSLPFLKHLAPHMP 1462

  Fly  1053 ----------------SGGGHSASTGGHQNHQGSSSASGSSAGASGATGGGAASHHQSHY 1096
                            .|...|.:.|..:..:|::....|...|:|..|...:|..:..|
Human  1463 LKTDMQSTESHSPEARVGSSESEAAGSLRPAEGAAPYRASVFAATGLPGSSPSSVFRLEY 1522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_572421.1	PXA	142..300	CDD:460484	24/161 (15%)
		RGS_SNX25	422..531	CDD:188675	26/165 (16%)
		PX_SNX25	645..788	CDD:132788	30/146 (21%)
		Nexin_C	882..987	CDD:462541	23/122 (19%)
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816
		Kinesin_assoc	364..476	CDD:465047
		FHA_KIF16B	446..562	CDD:438784
		Smc	<606..>1089	CDD:440809	104/611 (17%)