DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and snx13

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_021323912.1	Gene:	snx13 / 503733	ZFINID:	ZDB-GENE-050306-12	Length:	966	Species:	Danio rerio

Alignment Length:	1054	Identity:	234/1054 - (22%)
Similarity:	405/1054 - (38%)	Gaps:	233/1054 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LAVIWYYPTFFLFFAFVVYSLVLVFAAVAGTVYIHYIF-TTNEPTPPSRVPSRLLYNATKSNIFD 123
            |.|:.:..:|..|..|.:...:|.|  :.|...:..:| .||......|.....:. .|::.:..
Zfish    15 LGVVLFLISFGPFAIFYLAFYILCF--IGGGFVVLLLFGKTNSEKHLERCEHSYML-PTQTAVLK 76

  Fly   124 LPKPIKNPSNL-----PLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVVREDLWNA 183
            :.:.:|:.|.|     .|.....:|..|||:|::.|||::..|. |.::..:.....:|..:.||
Zfish    77 VLEEMKSESKLIKIDRRLTGSNIIDEPLQQVIQFALRDYIQYWY-YTLSDDETFLLEIRLTVQNA 140

  Fly   184 IQKIHERALRMDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADE----EKEM 244
            :.:...|:..:|........:|:....||...|.|:.:..|...|........|.|.    |.||
Zfish   141 LVEFSTRSKEVDWQPYFTTRLVDDFATHLRVFRKAQEKLNEKEDPKQRDDPDELLDSFFEVEVEM 205

  Fly   245 E-----------------FLRKLCEIMVILLLPRG-YSLPPLKVLLSEILSYKIFFPMIKMLTAP 291
            |                 :||.|||:::.||||.| :....::..|.|:|:..:..|:|..|:.|
Zfish   206 ERKICRDVVCMSRKDEEGYLRDLCEVLLYLLLPPGDFHSKNMRYFLREVLARGVLLPLINQLSDP 270

  Fly   292 DYINQKVVQNIETRLAAAAMSKRSYEYAASFEDFLKIINNSGNLEELSLIRKSIVNDLMHATTMQ 356
            |||||.|:..|.             :.:.::|.||.|:..:....||..::..:         ::
Zfish   271 DYINQFVIWMIR-------------DSSCNYEAFLNILKLTDEPSELEAVKDKV---------LE 313

  Fly   357 NLQRAKGLDPDHEDHSLSKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDIDLTLVE 421
            .||..:.||...:|.::.|:::.:.:.:|: |.:..:.:.:..|.:.......|:.....:.|..
Zfish   314 ELQYLRSLDTGSDDINIIKNQINSLLFVKK-VCETRIQRIQSGKEVDALKLAANFGKLCVIPLEH 377

  Fly   422 ILNTAVGRRYFTLFLEPLKASALIGFYLAVE--------------EIKHAHKSASHQ-------- 464
            ||...:..::|..:::.:...|::.|:|.||              ..:...|..|.|
Zfish   378 ILVHNIALQFFMDYMQCMGGQAILFFWLTVEGYRVTAQQQLEVLQSCQRDGKRQSSQTTKGLLRA 442

  Fly   465 --LGTEIFYTYIRVPKS-EIQIDKHE-RKLIETFLLGDAEPDIFYDIQRNV--LRTLEEKYYPPF 523
              ||  :|..|:....| .:|:|:.. .:|.:.....|..|:||.:|||.|  :....|.|||.|
Zfish   443 AALG--VFDQYLSEKASPRVQVDEASVTRLAQKLNKEDPTPEIFDEIQRKVYDMMLKHEHYYPSF 505

  Fly   524 VLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEP-LADEQPGAADGLNGGAGGAIDVAAHTSYA 587
            .....|.::...||.                ::|| ......|..:..||...|:|
Zfish   506 RQHPLYVRMLAELDM----------------LKEPSYRGSDDGDGESFNGSPTGSI--------- 545

  Fly   588 RRKLEQIQERIDKKNQALDALKYSVKPESKVLTILEKEMEWLKSEKRQTEAHLRRTDAWTEHLGK 652
                          |.:||.|...
Zfish   546 --------------NLSLDDLSSG----------------------------------------- 555

  Fly   653 WKATIQSVEVSDEKESLQFMILVHVDEDINAPVQPTSSKNGDSGHAN-------LRKRPSGISSG 710
                  ||   ||...|...|....|..:| |: |.:....|.|...       :||...|....
Zfish   556 ------SV---DESVQLHAFISDTADAFLN-PL-PVAGVCNDHGKTYALYTITVIRKNSDGSEDT 609

  Fly   711 WVVMRSLNQVHELQRKLRHVSSNLKAI-DLPTNFKFFFLKTDRHGQEKAKSQIQKFLNFILEDDH 774
            |...|..:..|:...::.....:|..| .||.  |..|...||...||.|..:..:|..:|..:.
Zfish   610 WKTYRRYSDFHDFHMRITEQFESLAPILKLPG--KKTFNNMDREFLEKRKKDLNAYLQLLLNPEM 672

  Fly   775 LNGSEAIYTFLSPSSDHLKQSLPSPKKSKFS---------LSTLFR--SDAGKAHEASKATDPFW 828
            :.....:..::   .|.|:....|..|.:|:         |.:..|  |:|.|:...|.|.
Zfish   673 VKACPILMPYV---YDFLENKAYSKGKREFARKMDTFVNPLRSSMRNVSNAVKSLPDSLAE---- 730

  Fly   829 GLQRDDEDISTYLDGESGGEAKM--------------------LAADLDSK--DSI-AEPMYALM 870
            |:.:...|:.. :..:.|.:.|.                    ::|.||..  |:| ...|..||
Zfish   731 GVSKVSADMGR-MSEKLGQDIKQSIFKVPPLIQKSDIDPEHCRVSAQLDDNVDDNIPLRVMLLLM 794

  Fly   871 GEIFDMGGVFKWLRKSLISFVQ----ITYGRTINRQIRESVAYLFEESMLHNYFSAILKSFWPGG 931
            .|:||:....:|||:::.:.:|    .|||.||||:|.:.|..:.....:.:|......|:||.|
Zfish   795 DEVFDLKDRNQWLRRNIKNLLQQLIKATYGDTINRKIVDHVDNMTSPEQVSDYVKRFRDSYWPNG 859

  Fly   932 VLASAYPTRSEDMREMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYE 996
            :||...|.|.:::|..|..|||..|...:|:.|.:::||...::|:|:||:..|:...|::|.|.
Zfish   860 ILAETPPRRDKNLRMRTRVAAKTTLLGIMPDELKHIIGADTTRKGILRVFEMFQHQPLNRRLVYV 924

  Fly   997 LLEILMIEFFPEIR 1010
            .||..:...||:.:
Zfish   925 FLEGFLETLFPQYK 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	50/178 (28%)
		RGS_SNX25	422..531	CDD:188675	33/136 (24%)
		PX_SNX25	645..788	CDD:132788	31/150 (21%)
		Nexin_C	882..987	CDD:285792	37/108 (34%)
snx13	XP_021323912.1	PXA	98..284	CDD:321992	52/199 (26%)
		RGS	378..513	CDD:321993	33/136 (24%)
		PX_SNX13	559..690	CDD:132783	30/137 (22%)
		Nexin_C	806..915	CDD:312222	37/108 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104136at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820