DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snz and snx27b

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_956834.1	Gene:	snx27b / 393512	ZFINID:	ZDB-GENE-040426-1529	Length:	569	Species:	Danio rerio

Alignment Length:	235	Identity:	55/235 - (23%)
Similarity:	98/235 - (41%)	Gaps:	45/235 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 LMHATTMQNLQR-----AKGLDPDHEDHSLSKSELTAAVR-LKRYVRQLTMAK--GE---CEKNL 402
            ::|    |||:|     |....|.....|||:.:|.|..| |:.|:.::...:  ||   .::.|
Zfish   207 ILH----QNLKREFANFAFPKLPGKWPFSLSEQQLDARRRGLEEYLEKVCSVRVIGESDIMQEFL 267

  Fly   403 AKFGWNGNYSSDIDLTL---------VEILNTAVGRRYFTLFLEPLKASALIGFYLAV-EEIKH- 456
            ::...|.|..||::|.:         |.:.......:.:...:..:...::...|.|: |.|.|
Zfish   268 SESDENYNGVSDVELRIAMPDKTTVTVRVRKNCTTDQVYQAVVTKIGMDSITASYFALFEVINHT 332

  Fly   457 -AHKSASHQLGTEIF---YTYIRVPKSEIQIDKHERKLIETFLLGDAEPDIFY-------DIQRN 510
             |.|.|.::...:::   || ..||.:.:.:.|......|..||.|.|..|.|       |:::.
Zfish   333 FARKLAPNEFPHKLYVQNYT-SAVPGTCLTLRKWLFTTEEEILLNDNELAINYCFHQALDDVKKG 396

  Fly   511 VLRTLEEKYYPPFVLSDQYRQ------LKEALDSNEIADP 544
            .:: :.||.|....|::|.:.      |:.....|||..|
Zfish   397 FIK-VGEKSYQLQKLTEQRKMTMYLSILRTCEGYNEITFP 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373
		RGS_SNX25	422..531	CDD:188675	26/121 (21%)
		PX_SNX25	645..788	CDD:132788
		Nexin_C	882..987	CDD:285792
snx27b	NP_956834.1	PDZ_signaling	46..138	CDD:238492
		PX_SNX27	165..270	CDD:132796	18/66 (27%)
		SNX27_RA	279..365	CDD:176372	15/86 (17%)
		FERM-like_C_SNX27	430..531	CDD:270146	4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030