DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and Snx25

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_224863.6	Gene:	Snx25 / 306471	RGDID:	1310150	Length:	986	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	314/979 - (32%)
Similarity:	506/979 - (51%)	Gaps:	129/979 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SLVLVFAAVA---GTVYIHYIFTTNEPTPPS------------RVPSRLLYNATKSNIFDLPKPI 128
            ||.|..||.|   ||: :..:..:....||.            |.|.|       |.::..|:
  Rat    79 SLYLSCAAAALLLGTL-VALVCWSPRAQPPDFASSWSRLAAAVRCPLR-------SPVYGNPQ-- 133

  Fly   129 KNPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVVREDLWNAIQKIHERALR 193
            :......::....:|..|:.:.:|..||::|.|.|.:......:..::.:|.|:..::|..|...
  Rat   134 ETAQGRRVVISHNMDRALKDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWDIAKQIRYRLSH 198

  Fly   194 MDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADEEKEMEFLRKLCEIMVILL 258
            :|..|::..|:|..:..|...::.|.||..|...|  |..::.|.|...|:.||:...:::|..|
  Rat   199 VDVVKVVCNDIVKALLTHFCDLKAATARHEEQPRP--FVLHACLKDSHDEVRFLQTCSQVLVFCL 261

  Fly   259 LP-RGYSLPPLKVLLSEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASF 322
            || :......|:.:|:|||:.|:..|::::|:.||||||.::..:|.|...:...||:|.||.|:
  Rat   262 LPSKDIQSLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLAQLEYREQMSGHHKRAYTYAPSY 326

  Fly   323 EDFLKIINNSGNLEELSLIRKSIVNDLMHATTMQN---LQRAKGLDPDHEDHSLSKSELTAAVRL 384
            |:|:|:||::.::|.|..:|..||.:::.|||:.:   |:|.||     ::.:..|::|..|..:
  Rat   327 EEFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKG-----KESAAMKTDLLRARNM 386

  Fly   385 KRYVRQLTMAKGECEKNLAKFG--------------WNGNYSSDIDLTLVEILNTAVGRRYFTLF 435
            |||:.|||:||.:|||.:...|              ..|..|..| |...:|:.....|..|..:
  Rat   387 KRYINQLTVAKKQCEKRIRILGGPAYDQQEDGVSDEGEGPQSQKI-LQFEDIMTNPFYRERFGTY 450

  Fly   436 LEPLKASALIGFYLAVEEIKHAHKSASHQLGTEIFYTYIRVPKSEIQIDKHERKLIETFLLGDAE 500
            :|.:...||:||:.:||.:|:|:|:...||.:|::..:. |...||.::|...|.|:..|:|:..
  Rat   451 MERIDKRALVGFWESVEHLKNANKNEIPQLVSEMYQNFF-VESKEIPVEKSLYKEIQQCLVGNKG 514

  Fly   501 PDIFYDIQRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPG 565
            .::|..||.:|...|.::|||.|::||.|.:|                   |.:.:|...|.|..
  Rat   515 IEVFSKIQGDVYDVLRDRYYPSFLVSDLYEKL-------------------IHEEEEETPDSQLA 560

  Fly   566 AAD---GLNGGAG-----GAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTIL 622
            :..   |..|.||     |...|:...|:|..||.::.|:::.|.|||.:::.:.||:.|:::.|
  Rat   561 SGKDELGSGGEAGEEVVEGTSGVSDPASFAVIKLRELSEKLEYKRQALSSIQNAPKPDKKIISKL 625

  Fly   623 EKEMEWLKSEKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEK-ESLQ-FMILVHVDEDINAPV 685
            :.|:..::.|....:.|:.|||.|.||||.|||:|.|.||::|. |.:. :.:.|::.|     |
  Rat   626 KDEILVIEKECTDLQLHMARTDWWCEHLGLWKASITSAEVTEENGEQMPCYFVRVNLQE-----V 685

  Fly   686 QPTSSKNGDSGHANLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPTNFKFFFLKT 750
            ....:||                  |.|.|.|::...|.|||.....:||.:.||:..|..|...
  Rat   686 GGVETKN------------------WTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSI 732

  Fly   751 DRHGQEKAKSQIQKFLNFILEDDHLNGSEAIYTFLSPSSDHLKQSLPSPKKSKFSLSTLFRSDAG 815
            |....||:|:|:.|||..:|.|:.|..|||:|.|||||.|:||......||:.||||:..
  Rat   733 DHKFLEKSKNQLNKFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFL----- 792

  Fly   816 KAHEASKATDPFWGLQ----RDDEDISTYLDGESGGEAKMLAADLDSKDSIAEPMYALMGEIFDM 876
                 .|....|:..|    .:|.|:|.|.|...|           .||::|||.:.|:||||::
  Rat   793 -----EKLPRDFFSHQEEEIEEDSDLSDYGDDVDG-----------KKDALAEPCFMLIGEIFEL 841

  Fly   877 GGVFKWLRKSLISFVQITYGRTINRQIRESVAYLFEESMLHNYFSAILKSFWPGGVLASAYPTRS 941
            .|:|||:|::||:.||:|:|||||:|||::|.::|.|.|:..|.||...:|||.|.||.....||
  Rat   842 RGMFKWVRRTLIALVQVTFGRTINKQIRDTVNWIFSEQMVVYYISAFRDAFWPNGKLAPPTRIRS 906

  Fly   942 EDMREMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILMIEFF 1006
            |...:.|...|:..|.::||:.|.:|||.|.|:.|::|:|.|||....||.|.|.|:|:|:.|..
  Rat   907 EAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETRANKHLLYVLMELLLTELC 971

  Fly  1007 PEIR 1010
            ||:|
  Rat   972 PELR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	46/157 (29%)
		RGS_SNX25	422..531	CDD:188675	36/108 (33%)
		PX_SNX25	645..788	CDD:132788	51/144 (35%)
		Nexin_C	882..987	CDD:285792	48/104 (46%)
Snx25	XP_224863.6	PXA	148..303	CDD:396666	46/156 (29%)
		RGS	437..545	CDD:413378	36/108 (33%)
		PX_SNX25	648..770	CDD:132788	51/144 (35%)
		Nexin_C	847..953	CDD:400794	48/105 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353233
Domainoid	1	1.000	101	1.000	Domainoid score	I6782
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23744
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1466
OMA	1	1.010	-	-		QHG50023
OrthoDB	1	1.010	-	-		D104136at33208
OrthoFinder	1	1.000	-	-		FOG0006633
OrthoInspector	1	1.000	-	-		oto97613
orthoMCL	1	0.900	-	-		OOG6_106742
Panther	1	1.100	-	-	O	PTHR22775
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910