DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and Rps6kc1

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_006250521.1	Gene:	Rps6kc1 / 289342	RGDID:	1306578	Length:	1045	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	152/736 - (20%)
Similarity:	250/736 - (33%)	Gaps:	235/736 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 PRGYSLPPLKVLLSEILSYKIFFPMIKMLTAPDYINQKVV-------QNIETRLAAAAMSKRSYE 317
            ||||::            ||:...::.... |:.:.:.:|       :.:...|  ..:.:.::.
  Rat    24 PRGYTI------------YKVTARVVSRRN-PEDVQEIIVWRRYSDFKKLHREL--WQIHRNAFR 73

  Fly   318 YAASFEDFLKIINNSGN---------LEELSLIRKSIVNDLMH-ATTMQNLQRAKGLDPDHEDHS 372
            ::..|..|.|     |.         :||    |:....||:. :..:..|..:|.|....:...
  Rat    74 HSELFPPFAK-----GTVFGRFDKTVIEE----RRQCAEDLLQFSANIPALYNSKQLQDFFKGGI 129

  Fly   373 LSK-SELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDIDL--------TLVEI------ 422
            :|. |||....  :.|...|.....||       |..| :|||.||        :|.|:
  Rat   130 ISDGSELIGPA--EAYPDSLANTFSEC-------GTEG-FSSDSDLLSLTVDADSLAEVDDGMAS 184

  Fly   423 ---------------LNTAVG----------------RRYFTLFLEPL--------KASALIGFY 448
                           .::|||                |..|...|:|.        ||..||...
  Rat   185 RQGSPSRAFGLSVSADSSAVGAVASDIEPSKAEDRESRSLFPSSLKPRLGRRDYLEKAGELIKLA 249

  Fly   449 LAVEEIKHAHKSAS--HQLGTEIFYTYIRVPKSEIQIDKHERKLIETFLLGDAEPDIFYDIQRNV 511
            |..|| :..:::||  ::.|.::....::...|..:.:..:|:..|..:..::...:      .|
  Rat   250 LKKEE-EDDYEAASDFYRKGVDLLLEGVQGESSPTRREAVKRRTAEYLMRAESICSL------RV 307

  Fly   512 LRTLEEKYYPPFVLSDQ----YRQLKEALDSNE---IADPTLLMCHTIGDVQEPLADEQPGAADG 569
            ...|:....||..||.:    .|...|.|.:..   :.|..||:..|        ..||.....|
  Rat   308 TAQLDTGPQPPGALSSRPPWNLRSPAEELKAFRVLGVIDKVLLVMDT--------RTEQTFILKG 364

  Fly   570 LNGGAGGAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTILEKE--------M 626
            |.           .:|...|..:.|..|.......|..  |.:..||..|.:...|        .
  Rat   365 LR-----------KSSECSRNRKTIIPRCVPNMVCLHT--YIISEESVFLVLQHAEGGKLWSYIS 416

  Fly   627 EWLKSEKRQT------------EAHLRRTDAWTEHLGKWKATIQSVEV--SDEKESLQFMILVHV 677
            ::|....|::            ...|::..|..:  |.:     |||.  ||....|:.:
  Rat   417 KFLNRSSRESLDIKEARPPMPPRVRLQQPSASPQ--GSY-----SVESRGSDTGSMLKVL----- 469

  Fly   678 DEDINAPVQPTS---SKNGDSGHANLRKRP-SGISS------GWVVMRSLNQVHELQRKLRHVSS 732
              .:...:.|:|   |...|.|..:..|.| ||.||      |::.:  .|:..  |.||...|.
  Rat   470 --PLKTSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTAGYLTL--CNEYG--QEKLDLTSL 528

  Fly   733 NLKAIDLPTNFKFFFLKTDRHGQEKAKSQIQKFLNFILEDDHLN---------GSEAIYTFLSP- 787
            |.:::..|..             |.|.||..:.....|..|..:         |.|.:....||
  Rat   529 NEESVMQPEG-------------ENADSQAVRSFPASLTADSASPSTQLKFFPGDEGLEAVCSPR 580

  Fly   788 SSDHLKQSLPSPKK-----SKFSLSTLFRSDAG-KAH----EASKATDPFWGLQRDDEDISTYLD 842
            :||.|::|..||.:     ||.|.|.|...|:| |.|    |..||   .:.|:..|....::..
  Rat   581 TSDSLRRSKNSPMEFFRIDSKDSTSELLGLDSGEKLHSLKPEPLKA---LFTLEDGDSPSQSFDA 642

  Fly   843 GESGGEAKMLAADLDSKDSIA 863
            |:|.||:       :::|||:
  Rat   643 GKSQGES-------EAQDSIS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	7/38 (18%)
		RGS_SNX25	422..531	CDD:188675	26/159 (16%)
		PX_SNX25	645..788	CDD:132788	37/164 (23%)
		Nexin_C	882..987	CDD:285792
Rps6kc1	XP_006250521.1	PX_RPK118_like	11..128	CDD:132820	21/127 (17%)
		MIT_SNX15	237..305	CDD:239140	13/68 (19%)
		PKc_like	334..>420	CDD:304357	20/106 (19%)
		STKc_RPK118_like	<858..1035	CDD:270728
		S_TKc	<867..1035	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900