Protein Alignment snz and RPS6KC1

DIOPT Version :9

• Sequence 1: NP_001284993.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_036556.2
• Gene: RPS6KC1 / 26750
• HGNCID: 10439
• Length: 1066
• Species: Homo sapiens
• Alignment Length: 1093
• Identity: 195/1093 - (17%)
• Similarity: 338/1093 - (30%)
• Gaps: 405/1093 - (37%)

  Fly   260 PRGYSLPPLKVL-----------LSEILSYK------------------------IFFPMIKMLT 289
            ||||::  .||.           :.||:.:|                        :|.|..|.:.
Human    24 PRGYTV--YKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIV 86

  Fly   290 APDYINQKVVQNIETRLAAAAMSKRSYEYAASF-----EDFLK--IINNSGNL------------ 335
            ...: ::.|::  |.|..|..:.:.|....|.:     |||.|  |||:|..|
Human    87 FGRF-DETVIE--ERRQCAEDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLI 148

  Fly   336 ---EELSLIRKSIVNDLMHAT--------------TMQNLQ-RAKGLDPDHEDHSL--------- 373
               .|.|....|..:||:..|              :.||.. |..||:...:..:|
Human   149 DTFPECSTEGFSSDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQ 213

  Fly   374 --------SKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNY--SSD-----IDLTLVEI- 422
                    |:|....:::.|...|......||..|...|.....:|  :||     :||.|..:
Human   214 SKTEEERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEGVQ 278

  Fly   423 ------LNTAVGRRYFTLFLEPLKASALIGFYLAVEEIKHAHKS-ASHQLGTEIFYTYIRVPKSE 480
                  ...||.||.....:.....|:|.| ...::::.....| :|..|..      :|.|..|
Human   279 GESSPTRREAVKRRTAEYLMRAESISSLYG-KPQLDDVSQPPGSLSSRPLWN------LRSPAEE 336

  Fly   481 IQ-------IDK----HERKLIETFLLGDAEPDIFYDIQRNVLRTLEEKYYPPFVLSDQY----- 529
            ::       |||    .:.:..:||:|........|...|   :|:..:..|..|...:|
Human   337 LKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNR---KTIIPRCVPNMVCLHKYIISEE 398

  Fly   530 -----------------------RQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPGA---AD 568
                                   |..:|:.|..|:..|||...|    :|:|.:..|..:   :.
Human   399 SVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVH----LQQPTSSPQDSSSFESR 459

  Fly   569 GLNGG-----------------------------------AGGAIDVAAHTSYARRKLEQIQERI 598
            |.:||                                   :|.:.:....|||.....|..||:|
Human   460 GSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEECTTSYLTLCNEYGQEKI 524

  Fly   599 D-----------KKNQALD--ALK-----YSVKPESKVLTILEKEMEWLKSEKRQTEAHLRRTDA 645
            :           .:...:|  |:|     .:...:|....:...|:::..::..:..:..|.:|:
Human   525 EPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLRAHELKFFPNDDPEAVSSPRTSDS 589

  Fly   646 WTEHLGKWKATIQSVEVSDEKESLQFMILVHVDEDI----NAPVQP-TSSKNGDSGHANLRKRPS 705
                |.:.|.:.......|.|:|...::.:...|.:    :.|::| .:..:|||...:.....|
Human   590 ----LSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSLKSEPLKPFFTLPDGDSASRSFNTSES 650

  Fly   706 GIS----------------------------SGWVVMR---------SLNQVHE----------- 722
            .:.                            ||....|         .|....|
Human   651 KVEFKAQDTISRGSDDSVPVISFKDAAFDDVSGTDEGRPDLLVNLPGELESTREAAAMGPTKFTQ 715

  Fly   723 -----LQRKL-----------------RHVSSNLKAIDLPTNFKFFFLKTDRHGQEKAKSQIQKF 765
                 ::.||                 .|....::.:..|:..|.:.:....:.||..:
Human   716 TNIGIIENKLLEAPDVLCLRLSTEQCQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPR------ 774

  Fly   766 LNFILEDDHLNGSEAIYTFLSPSSDHLKQSL---PSPKKSKFSLSTLFR--------------SD 813
            :.|:...||.:..:   ..|.||||...|.|   .|...:..:..:|||              :|
Human   775 MLFVAAVDHSSSGD---MSLLPSSDPKFQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTD 836

  Fly   814 AGKAHEASKATD---------PFWGLQRDDEDISTYLDGESG------GEAKMLAADLDSKDSIA 863
            ..|..|....||         |....|||.|     ..||||      .|...:..|||.|.::|
Human   837 TLKTEEVLLFTDQTDDLAKEEPTSLFQRDSE-----TKGESGLVLEGDKEIHQIFEDLDKKLALA 896

  Fly   864 EPMYALMGEIFDMGGVFKWLRKSLISF-------------------------VQITYGRTINR-- 901
            ...|      ...|.:.:|..:.:::.                         :|:||   .:|
Human   897 SRFY------IPEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTY---FSRWS 952

  Fly   902 QIRES--------------VAYLFEESMLHNYFS--AILKSFWPGGVLASAYPT-----RSEDMR 945
            ::.:|              |..:.||:...:::|  |:|.....|..|...:|.     .:.:|.
Human   953 EVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP 1017

  Fly   946 EMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELL 998
            |..:..|::|:...:.......:||     ||..|.|...:|.:....:.||:
Human  1018 ECVSEEARSLIQQLLQFNPLERLGA-----GVAGVEDIKSHPFFTPVDWAELM 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	12/73 (16%)
		RGS_SNX25	422..531	CDD:188675	25/155 (16%)
		PX_SNX25	645..788	CDD:132788	28/217 (13%)
		Nexin_C	882..987	CDD:285792	25/152 (16%)
RPS6KC1	NP_036556.2	PX_RPK118_like	11..128	CDD:132820	22/108 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..228		2/20 (10%)
		MIT_SNX15	238..312	CDD:239140	17/74 (23%)
		PKc_like	335..>421	CDD:304357	13/88 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..509		8/71 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..596		6/46 (13%)
		S_TKc	<875..1056	CDD:214567	34/194 (18%)
		STKc_RPK118_like	<879..1056	CDD:270728	34/190 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900