Protein Alignment snz and SNX13

DIOPT Version :9

• Sequence 1: NP_001284993.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_001337791.1
• Gene: SNX13 / 23161
• HGNCID: 21335
• Length: 968
• Species: Homo sapiens
• Alignment Length: 1078
• Identity: 246/1078 - (22%)
• Similarity: 406/1078 - (37%)
• Gaps: 279/1078 - (25%)

  Fly    54 GITLTLLA---VIWYYPTFFLFFAFVVYSLV--LVFAAVAGTVYI----HYIFTTNEPTPPS--- 106
            ||.|.|:.   .:.:|.||:: ..||...||  |:|.......|:    |.......|..|.
Human    16 GIVLFLITFGPFVIFYLTFYI-LCFVGGGLVVTLLFGKTNSEKYLEQCEHSFLPPTSPGVPKCLE 79

  Fly   107 ---------RVPSRLLYNATKSNIFDLPKPIKNPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWL 162
                     ::..||    |.:||.|.|                    |||:|::.|||::..|.
Human    80 EMKREARTIKIDRRL----TGANIIDEP--------------------LQQVIQFSLRDYVQYWY 120

  Fly   163 GYVVTKPKLINDVVREDLWNAIQKIHERALRMDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNT 227
             |.::..:.....:|:.|.||:.:...|:..:|........:|:....||...|.|:.:..|.:
Human   121 -YTLSDDESFLLEIRQTLQNALIQFATRSKEIDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKD- 183

  Fly   228 PPVFSTNSYLADE----EKEME-----------------FLRKLCEIMVILLLPRG-YSLPPLKV 270
            ..|..|...|.|.    |.|||                 |||.|||:::.||||.| :....::.
Human   184 DQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLRDLCEVLLYLLLPPGDFQNKIMRY 248

  Fly   271 LLSEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASFEDFLKIINNSGNL 335
            .:.|||:..|..|:|..|:.||||||.|:..|.             :...::|.|:.||..|.|:
Human   249 FVREILARGILLPLINQLSDPDYINQYVIWMIR-------------DSNCNYEAFMNIIKLSDNI 300

  Fly   336 EELSLIRKSIVNDLMHATTMQNLQRAKGLDPDHEDHSLSKSELTAAVRLKRY----VRQLTMAKG 396
            .||..:|..         ..:.||..:.||...:|.:..|:::.:.:.:|:.    :::|...|
Human   301 GELEAVRDK---------AAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGK- 355

  Fly   397 ECEKNLAKFGWNGNYSSDIDLTLVEILNTAVGRRYFTLFLEPLKASALIGFYLAVEEIK------ 455
              |.|..|..  .|:.....:.|..||...|..::|..:::.....|.:.|::.||..:
Human   356 --EINTVKLA--ANFGKLCTVPLDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQ 416

  Fly   456 -----HAHKSASHQ----------LGTEIFYTYIRVPKS-EIQIDKH-ERKLIETFLLGDAEPDI 503
                 ...:...||          ....|:..|:....| .:.:|.: ..||.:|....|..|:|
Human   417 LEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYLSEKASPRVTVDDYLVAKLADTLNHEDPTPEI 481

  Fly   504 FYDIQRNV--LRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPGA 566
            |.||||.|  |...:|::||.|..:..|.::...||.  :.||:             ......|.
Human   482 FDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDM--LKDPS-------------FRGSDDGD 531

  Fly   567 ADGLNGGAGGAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTILEKEMEWLKS 631
            .:..||...|:|                       |.:||.|. :|..:..|
Human   532 GESFNGSPTGSI-----------------------NLSLDDLS-NVSSDDSV------------- 559

  Fly   632 EKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEKESLQFMILVHVDEDINAPVQPTSSKNGDSG 696
               |..|::..|                               |:.|.|..|    .:....|.|
Human   560 ---QLHAYISDT-------------------------------VYADYDPYA----VAGVCNDHG 586

  Fly   697 HA------NLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAI-DLPTNFKFFFLKTDRHG 754
            ..      .:.:|.......|...|..:..|:...::.....:|.:| .||.  |..|...||..
Human   587 KTYALYAITVHRRNLNSEEMWKTYRRYSDFHDFHMRITEQFESLSSILKLPG--KKTFNNMDRDF 649

  Fly   755 QEKAKSQIQKFLNFILEDDHLNGSEA----IY--------------------TFLSPSSDHLKQS 795
            .||.|..:..:|..:|..:.:..|.|    :|                    ||::|..:.::..
Human   650 LEKRKKDLNAYLQLLLAPEMMKASPALAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNV 714

  Fly   796 LPSPKKSKFSLS---TLFRSDAGKAHEASKATDPFWGLQRDDEDISTYL--------DGESGGEA 849
            ..:.|....||:   |....:.||..|            |..:||....        ..:|..|.
Human   715 SNAVKSLPDSLAEGMTKMSDNMGKMSE------------RLGQDIKQSFFKVPPLIPKTDSDPEH 767

  Fly   850 KMLAADLDSK--DSI-AEPMYALMGEIFDMGGVFKWLRKSLISFVQ----ITYGRTINRQIRESV 907
            :.::|.||..  |:| ...|..||.|:||:....:|||:::.:.:|    .|||.||||:|.:.|
Human   768 RRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTINRKIVDHV 832

  Fly   908 AYLFEESMLHNYFSAILKSFWPGGVLASAYPTRSEDMREMTTTAAKALLTDHIPEVLCNLVGAQA 972
            .::.....:.:.......:|||.|:||.|.|.|.:.:|..|..|.|..|...:|:.|.:::||:.
Human   833 DWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAET 897

  Fly   973 AKRGVLKVFDALQNPAYNKQLFYELLEILMIEFFPEIR 1010
            .::|:|:||:..|:...|:::.|..||..:...||:.:
Human   898 TRKGILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYK 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	53/178 (30%)
		RGS_SNX25	422..531	CDD:188675	32/133 (24%)
		PX_SNX25	645..788	CDD:132788	28/173 (16%)
		Nexin_C	882..987	CDD:285792	36/108 (33%)
SNX13	NP_001337791.1	PXA	97..284	CDD:214611	59/221 (27%)
		RGS_SNX13	377..511	CDD:188674	32/133 (24%)
		PX_SNX13	557..687	CDD:132783	30/182 (16%)
		Nexin_C	803..911	CDD:312222	35/107 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5758
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104136at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.800