DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and snx-13

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_503026.3	Gene:	snx-13 / 178482	WormBaseID:	WBGene00013803	Length:	940	Species:	Caenorhabditis elegans

Alignment Length:	1080	Identity:	240/1080 - (22%)
Similarity:	417/1080 - (38%)	Gaps:	266/1080 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LLAVIWYYPTFFLFFAFVVYSLVLVFAAVAGTVYIHYIFTTNEPTPPSRVPSRLLYNATKSNI-F 122
            ||||:.:..||......|:.:.:|.|  |||.:||.| .|.:|  ....:...|..|..|..: .
Worm     8 LLAVVLFLATFGSTGLIVLPASILCF--VAGFLYIFY-QTGHE--KHDEIAGILSENLQKGKLSA 67

  Fly   123 DLPKPIKNPSNL----------PLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVVR 177
            .:...:||...|          .:.....:||.|:||:..:.||::..|.      ..|.||.:.
Worm    68 GIEALLKNGKRLKEQNQYVEVHSMCNSPQLDLVLEQILGNITRDYVGFWY------KTLSNDNIF 126

  Fly   178 EDLWNAIQKIHERAL--------RMDAAKIIAVDMVNRVTVHLEKIRIAEARAA-------ETNT 227
            |   .::::...|::        ::|...::..|:|:....||...|.|:.|.|       :|.:
Worm   127 E---QSLKRTSRRSIASLTQCLRQVDWVPLLTRDVVDDFASHLRLFRKAKERTAFQAKEKDKTLS 188

  Fly   228 PPVFSTN--SYLADEEKEME-----------------FLRKLCEIMVILLL-PRGYSLPPLKVLL 272
            |......  |...|.|.|||                 :|..|.:|::.|:: |..:...||:.||
Worm   189 PEDLEAELLSNFFDFELEMEKSLCRDLLSTTPHYENAYLHDLVDIILYLIMPPEDFRCRPLRFLL 253

  Fly   273 SEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASFEDFLKIINNSGNLEE 337
            .|::..|:..|.:..|:.|:.|.|.:|..:.             |.....:||:..:.:|.::||
Worm   254 REVVVRKVILPTLDYLSDPNEIFQLIVWLLS-------------EVEPKPDDFVACLTSSTSIEE 305

  Fly   338 LSLIRKSIVNDLMHATTMQNLQRAKGLDPDHEDHSLSKSELTAAVRLKRYV-RQLTMAKGECEKN 401
            |..:.::|.::.:         ..:|.|...|..:..|.:|.:...::..| |::.....:....
Worm   306 LEAVFRAIADEKI---------VMRGKDSGGEQDTFVKQQLASLQFVENLVQRRIDFLGSKDSAL 361

  Fly   402 LAKFGWNGNYSSDIDLTLV-----------EILNTAVGRRYFTLFLEPLKASALIGFYLAVEE-- 453
            |.|||.:|:....:.|.::           |.|.:|.|:.|..|:|      |:.||.::||.
Worm   362 LTKFGEDGDQLVQLPLHVILTNSIALSQFCEFLKSAGGQNYIDLYL------AIEGFKVSVEHQM 420

  Fly   454 ----------------IKHAHKSASHQLGTEIFYTYIRVPKSEIQIDKHERKLIETFL--LGDAE 500
                            :|.|.|....|..:|...|  |||.        |..||..||  |.:.|
Worm   421 RSLSKGELSESDAYETVKEAAKYMYDQYLSEEAIT--RVPL--------EDALISRFLQSLKNDE 475

  Fly   501 P-DIFYD-IQRNVLRTL--EEKYYPPFVLSDQYRQL---KEALDSNEIADPTLLMCHTIGDVQEP 558
            | |:::: ||..|:..|  ::.::|.|..|..|.::   .|.:|.:. .||||..|.::
Worm   476 PHDLWFESIQEKVIEVLKTDDHFFPAFKKSAGYVKMLLELEIIDEDR-NDPTLSECDSV------ 533

  Fly   559 LADEQPGAADGLNGGAGGAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTILE 623
                                     ||::     ..|:|.:....||..:...|
Worm   534 -------------------------TSFS-----SSQDRSEDCESALRKMSIEV----------- 557

  Fly   624 KEMEWLKSEKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEKESLQFMILVHVDEDINAPVQPT 688
                               .|...|......||::::.:..:.:....:..|.|...:|.
Worm   558 -------------------VDGPLEDEPVMTATVETLGIGHQGKQTYALYNVRVSRCVNG----- 598

  Fly   689 SSKNGDSGHANLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPTNFKFFFLKTDRH 753
                        |:     .|.|.|:|..:..|.|.:.|......|..:..|.  |..|...|..
Worm   599 ------------RE-----VSSWNVIRRYSDFHTLHQVLVQKFPKLSTLSFPG--KKTFNNLDNE 644

  Fly   754 GQEKAKSQIQKFLNFILEDDHLNG----SEAIYTFLSPSSDHLKQSLPSPKKSKFSLSTLFR--S 812
            ..||....:..:|:.||:...|..    ...::.|||..    |.:..:|...|| :|.:|.  .
Worm   645 FLEKRTKALNMYLSCILQPHLLRNYPEMDRHVFDFLSQK----KYANSNPLTKKF-MSAMFDPIR 704

  Fly   813 DAGKAHEASKATDP---FWGLQRDDEDIST----YLDGESGG--------EAKMLAADLDSKDSI 862
            :..||...:....|   |.|:.:....|:.    .::..|..        |...:||.|...:|.
Worm   705 NGVKAVGTTVMAVPDQVFEGVTKMGVGINNAAKIIINPSSSSTVNRPPVMETDRVAASLTDTESE 769

  Fly   863 AEPMYAL---MGEIFDMGGVFKWLRKSLISFVQ--IT-YGRTINRQIRESVAYLFEESMLHNYFS 921
            ..|:..|   :.|:|...| ..|.|:.|::.::  :| :|.:||::|.:.|.:|..|..:..|.:
Worm   770 NIPLRVLVLVVSEVFGAQG-SAWFRRQLVTVIKHIVTPFGTSINKRIVDIVNWLTSEQQVGGYLN 833

  Fly   922 AILKSFWPGGVLASAYPTRSEDMREMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQN 986
            :..:|.||.|.||:.|..:..::...|...||.|:...:|:.|..::||..:.:|:..:.:|.||
Worm   834 SFRESMWPNGELAAEYVEKPPELHHKTRLLAKTLMLSSLPDELRIILGANVSYKGINTISEAFQN 898

  Fly   987 PAYNKQLFYELLEILMIEFFPEIRQLRV-----SNSNGTK 1021
            ...|::|.|.|||..:|:.||..|..::     |.|..||
Worm   899 KNLNRRLLYVLLERTLIKVFPSNRFEKIFAQLHSKSPRTK 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	46/191 (24%)
		RGS_SNX25	422..531	CDD:188675	37/132 (28%)
		PX_SNX25	645..788	CDD:132788	28/146 (19%)
		Nexin_C	882..987	CDD:285792	30/107 (28%)
snx-13	NP_503026.3	PXA	95..283	CDD:280373	47/196 (24%)
		RGS_SNX13	380..510	CDD:188674	38/145 (26%)
		PX_domain	564..683	CDD:295365	27/142 (19%)
		Nexin_C	791..899	CDD:285792	30/107 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I6701
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I2785
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104136at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18013
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.000