DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snz and SNX20

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_878274.1	Gene:	SNX20 / 124460	HGNCID:	30390	Length:	316	Species:	Homo sapiens

Alignment Length:	333	Identity:	69/333 - (20%)
Similarity:	118/333 - (35%)	Gaps:	98/333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 TMQNLQRAKGLDPD--------HED-HS-LSKSELTAAVRLKRY-------------VRQLTMAK 395
            |.:..|.|....||        |.| || ||.:.......|::|             :.::..|:
Human    20 TARTQQEAPATGPDLPHPGPDGHLDTHSGLSSNSSMTTRELQQYWQNQKCRWKHVKLLFEIASAR 84

  Fly   396 GECEKNLAKFG-------WNGNYSSDIDLTLVEILNTAVGRRYFTLFLEPLKASALIGFYLAVEE 453
            .| |:.::||.       ..|::.:          |.||..|.::.|.: |:.:.|..|...:|:
Human    85 IE-ERKVSKFVVYQIIVIQTGSFDN----------NKAVLERRYSDFAK-LQKALLKTFREEIED 137

  Fly   454 IKHAHKSASHQLGTEIFYTYIRVPKS------EIQIDKHERKLIETFLLGDAEPDIFYDIQRNVL 512
            ::...|..:.....|:.....|..:.      .|:..:..|:.:: ||   ..|::     |...
Human   138 VEFPRKHLTGNFAEEMICERRRALQEYLGLLYAIRCVRRSREFLD-FL---TRPEL-----REAF 193

  Fly   513 RTLEEKYYP-PFVLSDQYRQLKEALDSN--EIADPTL---LMCHTIGDVQEPLADEQPGAADGLN 571
            ..|....|| ...|..:...|:|.|.::  ..|.|.|   |:||.  |:..|        |:...
Human   194 GCLRAGQYPRALELLLRVLPLQEKLTAHCPAAAVPALCAVLLCHR--DLDRP--------AEAFA 248

  Fly   572 GGAGGAIDVAAHTSYARRKLEQIQERIDKKNQA--LDALKYSVKPESKVLTILEKEMEWLKSEKR 634
            .|              .|.|:::|.|...:..|  |||:........|....|::.:|
Human   249 AG--------------ERALQRLQAREGHRYYAPLLDAMVRLAYALGKDFVTLQERLE------- 292

  Fly   635 QTEAHLRR 642
              |:.|||
Human   293 --ESQLRR 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373
		RGS_SNX25	422..531	CDD:188675	22/115 (19%)
		PX_SNX25	645..788	CDD:132788
		Nexin_C	882..987	CDD:285792
SNX20	NP_878274.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..54		10/30 (33%)
SNX20	NP_878274.1	PX_SNX20	76..189	CDD:132833	23/128 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900