DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snz and Snx25

DIOPT Version :9

Sequence 1:	NP_001284993.1	Gene:	snz / 31704	FlyBaseID:	FBgn0029976	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001359271.1	Gene:	Snx25 / 102141	MGIID:	2142610	Length:	986	Species:	Mus musculus

Alignment Length:	969	Identity:	314/969 - (32%)
Similarity:	510/969 - (52%)	Gaps:	109/969 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 SLVLVFAAVA---GTVYIHYIFTTNEPTPPSRVPSRLLYNAT-----KSNIFDLPKPIKNPSNLP 135
            ||.|..||.|   ||: :..:..:....||..|.|.....||     :|.::..|:  :......
Mouse    79 SLYLSCAAAALLLGTL-VSLVCWSPRAQPPDFVSSWSRLAATVRCPLRSPVYGNPQ--ETAQGRR 140

  Fly   136 LIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVVREDLWNAIQKIHERALRMDAAKII 200
            ::....:|..|:.:.:|..||::|.|.|.:......:..::.:|.|..:::|.:|...:|..|::
Mouse   141 VVISHNMDRVLRDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWEIVKQIRQRLSHVDVVKVV 205

  Fly   201 AVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADEEKEMEFLRKLCEIMVILLLP-RGYS 264
            ..|:|..:..|...::.|.||..|...|  |..::.|.|...|:.||:...:::|:.||| :...
Mouse   206 CNDIVKALLTHFCDLKAATARHEEQPRP--FVLHACLKDSHDEVRFLQTCSQVLVLCLLPSKDIQ 268

  Fly   265 LPPLKVLLSEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASFEDFLKII 329
            ...|:.:|:|||:.|:..|::::|:.||||||.:::.:|.|...:...||:|.||.|:|||:|:|
Mouse   269 SLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLRQLEYREQMSEHHKRAYTYAPSYEDFIKLI 333

  Fly   330 NNSGNLEELSLIRKSIVNDLMHATTMQN---LQRAKGLDPDHEDHSLSKSELTAAVRLKRYVRQL 391
            |::.:::.|..:|..||.:::.|||:.:   |:|.||     ::.:..|::|..|..:|||:.||
Mouse   334 NSNSDVDFLKQLRYQIVVEIIQATTISSFPQLKRHKG-----KESAAMKTDLLRARNMKRYINQL 393

  Fly   392 TMAKGECEKNLAKFG--------------WNGNYSSDIDLTLVEILNTAVGRRYFTLFLEPLKAS 442
            |:||.:|||.:...|              ..|..|..| |...:|:.....|..|..::|.:...
Mouse   394 TVAKKQCEKRIRILGGPAYDQQEDGASDEGEGPQSQKI-LQFEDIMTNPFYRERFGTYMERIDKR 457

  Fly   443 ALIGFYLAVEEIKHAHKSASHQLGTEIFYTYIRVPKSEIQIDKHERKLIETFLLGDAEPDIFYDI 507
            ||:||:.:.|.:|:|:||...||.:|::..:. |...||.::|...|.|:..|:|:...::|..|
Mouse   458 ALVGFWESAEHLKNANKSEIPQLVSEMYQNFF-VESKEISVEKSLYKEIQQCLVGNRGIEVFSKI 521

  Fly   508 QRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPGAADGLNG 572
            |.:|...|.|:|||.|::||.|.:|   :...|..:|         |.|  ||.|:.....|  |
Mouse   522 QADVSEVLRERYYPSFLVSDLYEKL---MREEEEEEP---------DAQ--LASEKDELGSG--G 570

  Fly   573 GAG-----GAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTILEKEMEWLKSE 632
            .||     |...|:...|:|..||.::.|:::.|.|||.:::.:.||:.|:::.|:.|:..::.|
Mouse   571 EAGEEAVEGTSGVSDPASFAVIKLRELNEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKE 635

  Fly   633 KRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEK-ESLQ-FMILVHVDEDINAPVQPTSSKNGDS 695
            ....:.|:.|||.|.|:||.|:|:|.|.||::|. |.:. :.:.|::.|     |....:||
Mouse   636 CTALQLHMARTDWWCENLGLWRASITSAEVTEENGEQMPCYFVRVNLQE-----VGGVETKN--- 692

  Fly   696 GHANLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPTNFKFFFLKTDRHGQEKAKS 760
                           |.|.|.|::...|.|||.....:||.:.||:..|..|...|.....|:::
Mouse   693 ---------------WTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGKSRN 742

  Fly   761 QIQKFLNFILEDDHLNGSEAIYTFLSPSSDHLKQSLPSPKKSKFSLSTLFRSDAGKAHEASKATD 825
            |:..||..:|.|:.|..|||:|.|||||.|:||......||:.||||:..          .|...
Mouse   743 QLNAFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFL----------EKLPR 797

  Fly   826 PFWGLQ----RDDEDISTYLDGESGGEAKMLAADLDSKDSIAEPMYALMGEIFDMGGVFKWLRKS 886
            .|:..|    .:|.|:|.|.|...|           .|||:|||.:.|:||||::.|:|||:|::
Mouse   798 DFFSHQEEEIEEDSDLSDYGDDVDG-----------KKDSLAEPCFMLIGEIFELRGMFKWVRRT 851

  Fly   887 LISFVQITYGRTINRQIRESVAYLFEESMLHNYFSAILKSFWPGGVLASAYPTRSEDMREMTTTA 951
            ||:.||:|:|||||:|||::|:::..|.||..|.||...:|||.|.||.....||....:.|...
Mouse   852 LIALVQVTFGRTINKQIRDTVSWISSEQMLVYYISAFRDAFWPNGKLAPPTRIRSVAQSQETKQR 916

  Fly   952 AKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILMIEFFPEIR 1010
            |:..|.::||:.|.:|||.|.|:.|::|:|.|||....||.|.|.|:|:|:.|..||:|
Mouse   917 AQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETKANKHLLYVLMELLLTELCPELR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_001284993.1	PXA	142..299	CDD:280373	46/157 (29%)
		RGS_SNX25	422..531	CDD:188675	37/108 (34%)
		PX_SNX25	645..788	CDD:132788	46/144 (32%)
		Nexin_C	882..987	CDD:285792	47/104 (45%)
Snx25	NP_001359271.1	PXA	148..303	CDD:366970	46/156 (29%)
		RGS	437..545	CDD:383028	37/108 (34%)
		End3	<558..645	CDD:372297	26/90 (29%)
		PX_SNX25	648..770	CDD:132788	46/144 (32%)
		Nexin_C	847..950	CDD:370015	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849582
Domainoid	1	1.000	97	1.000	Domainoid score	I7277
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23744
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1539
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50023
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006633
OrthoInspector	1	1.000	-	-		oto94088
orthoMCL	1	0.900	-	-		OOG6_106742
Panther	1	1.100	-	-	O	PTHR22775
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	1	1.000	-	-		X6390
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790