Protein Alignment spidey and Hsd17b12

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_114455.2
• Gene: Hsd17b12 / 84013
• RGDID: 708367
• Length: 312
• Species: Rattus norvegicus
• Alignment Length: 301
• Identity: 141/301 - (46%)
• Similarity: 197/301 - (65%)
• Gaps: 22/301 - (7%)

  Fly    22 FQVFRKVLPWIYAN--VVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISR 84
            :.:||....|...|  .|||          ::||||||||.||||||:||:|||:||:|:|||||
  Rat    28 YSLFRAFQVWCVGNQAFVGP----------RLGEWAVVTGGTDGIGKSYAEELAKRGMKIVLISR 82

  Fly    85 SLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLD 149
            |.:||..|:..|.:|:.||.|.|.|||: .|:|||||:...:||.:||||||||:||.:|||||:
  Rat    83 SQDKLKEVSNNIKEKFNVETRTIAVDFS-LDDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLE 146

  Fly   150 CYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVN 214
            ....|.. ::.::..|:.|:..:|.|.||||:.:.:|||:|:||.:|::|.|||:|||:|||||:
  Rat   147 IPDLDNT-IKKLININVLSICKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVD 210

  Fly   215 KFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPH 279
            .||..|..|||..||.:|||.|.||||.::||||.::..||.||:|:||:.|:|:.|:|.||:.|
  Rat   211 FFSQCLHEEYKSKGIFVQSVLPFFVATKLAKIRKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIH 275

  Fly   280 ALLQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAKE 320
            |::..:        .....|.|..|.|:|..|....|..|:
  Rat   276 AIMGSI--------NSILPRWIYFKTIMGFNKSLRNRYLKK 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	126/235 (54%)
Hsd17b12	NP_114455.2	17beta-HSD1_like_SDR_c	50..289	CDD:187614	127/248 (51%)
		Di-lysine motif. /evidence=ECO:0000250	308..312		0/1 (0%)