Protein Alignment spidey and HSDL1

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_113651.4
• Gene: HSDL1 / 83693
• HGNCID: 16475
• Length: 330
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 122/280 - (43%)
• Similarity: 175/280 - (62%)
• Gaps: 18/280 - (6%)

  Fly    43 GSSVDLSKM-GEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRV 106
            ||..||.|. |.||||:|:|||||||||:|||.|||.::||||:.|||.||||:|.|.|.||..:
Human    57 GSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDI 121

  Fly   107 IDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTH 171
            |..||:.|.|||..|||.....:||:||||||:.|.:|:||.   :.....|.:|:..||.:.:.
Human   122 IVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFT---QLSEDKLWDIINVNIAAASL 183

  Fly   172 MTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQP 236
            |..:.||||:.:::|.|:.:||.:...|.|.|:.:|::||:::.||..||.||...||.:||:.|
Human   184 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP 248

  Fly   237 GFVATNMSK----IRKASVFAPSPETYVRSALSTLGIATQTAGYLPHALLQLVIHFTEA---VFG 294
            .:|||:|:.    :.:.|...|||:.|...|:|||||:.:|.||..|::..|...:...   |:|
Human   249 FYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWG 313

  Fly   295 EQFARNIVMKNILGTRKRAL 314
                .||:.:::   ||.||
Human   314 ----ANILNRSL---RKEAL 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	109/239 (46%)
HSDL1	NP_113651.4	Required for mitochondria translocation	2..82		16/24 (67%)
		17beta-HSD1_like_SDR_c	67..309	CDD:187614	109/244 (45%)