Protein Alignment spidey and Hsd17b12

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_062631.1
• Gene: Hsd17b12 / 56348
• MGIID: 1926967
• Length: 312
• Species: Mus musculus
• Alignment Length: 302
• Identity: 140/302 - (46%)
• Similarity: 199/302 - (65%)
• Gaps: 22/302 - (7%)

  Fly    22 FQVFRKVLPWIYAN--VVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISR 84
            :.:||....|...|  :|||          ::||||||||.|||||||||:|||:||:|:|||||
Mouse    28 YSLFRAFQVWCVGNEALVGP----------RLGEWAVVTGGTDGIGKAYAEELAKRGMKIVLISR 82

  Fly    85 SLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLD 149
            |.:|||.|:..|.:|:.||.|.|.|||: .|:|||||:...:||.:||||||||:||.:|||||:
Mouse    83 SQDKLNQVSNNIKEKFNVETRTIAVDFS-LDDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLE 146

  Fly   150 CYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVN 214
            ....|.. ::.::..|:.||..:|.|.||||:.:.:|||:|:||.:|::|.|||::||:|||||:
Mouse   147 IPDLDNT-IKKLININVLSVCKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTIYSATKAFVD 210

  Fly   215 KFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPH 279
            .||..|..|||..||.:|||.|..|||.::||:|.::..||.||:|:||:.|:|:.|:|.||:.|
Mouse   211 FFSQCLHEEYKSKGIFVQSVMPYLVATKLAKIQKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIH 275

  Fly   280 ALLQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAKEQ 321
            :|:..:        .....|.:..|.|:|..|....|..|::
Mouse   276 SLMGSI--------NSIMPRWMYFKIIMGFSKSLRNRYLKKR 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	126/235 (54%)
Hsd17b12	NP_062631.1	Rossmann-fold NAD(P)(+)-binding proteins	<4..>83	CDD:473865	34/64 (53%)
		17beta-HSD1_like_SDR_c	50..288	CDD:187614	126/247 (51%)
		Di-lysine motif. /evidence=ECO:0000250	308..312		0/2 (0%)