DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spidey and HSD17B12

DIOPT Version :9

Sequence 1:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_057226.1	Gene:	HSD17B12 / 51144	HGNCID:	18646	Length:	312	Species:	Homo sapiens

Alignment Length:	303	Identity:	139/303 - (45%)
Similarity:	199/303 - (65%)	Gaps:	20/303 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VGFQVFRKVLPWIYANV--VGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLI 82
            :.:.:|..:..|...|.  |||          .:|||||||||||||||:||:|||:.|:|:|||
Human    26 ISYSLFTALRVWGVGNEAGVGP----------GLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLI 80

  Fly    83 SRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYF 147
            |||.:||:.|:.||.:|:.||.|.|.||| ..::|||||:....||.:|:||||||:||.:||||
Human    81 SRSKDKLDQVSSEIKEKFKVETRTIAVDF-ASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYF 144

  Fly   148 LDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAF 212
            ||....| ..::.::..||.||..||.|.||||:.:.:|.|:|:||.:|::|.|||::||:||.|
Human   145 LDVPDLD-NVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTF 208

  Fly   213 VNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYL 277
            |:.||..|..||:..|:.:|||.|.||||.::||||.::..|||||:|:||:.|:|:.::|.|||
Human   209 VDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYL 273

  Fly   278 PHALL-QLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAK 319
            .|||: .::.:....::     ..|||.....||...|::..|
Human   274 IHALMGSIISNLPSWIY-----LKIVMNMNKSTRAHYLKKTKK 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	139/303 (46%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	126/236 (53%)
HSD17B12	NP_057226.1	NADB_Rossmann	<3..>83	CDD:304358	32/66 (48%)
		DltE	50..300	CDD:223377	129/256 (50%)
		17beta-HSD1_like_SDR_c	50..289	CDD:187614	126/240 (53%)
		Di-lysine motif	308..312		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2934
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H95094
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3211
Isobase	1	0.950	-	0.803099	Normalized mean entropy	S1433
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		oto91626
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	1	1.100	-	-	LDO	PTHR43899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R721
SonicParanoid	1	1.000	-	-		X484
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.820