Protein Alignment spidey and HSD17B12

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_057226.1
• Gene: HSD17B12 / 51144
• HGNCID: 18646
• Length: 312
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 139/303 - (45%)
• Similarity: 199/303 - (65%)
• Gaps: 20/303 - (6%)

  Fly    20 VGFQVFRKVLPWIYANV--VGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLI 82
            :.:.:|..:..|...|.  |||          .:|||||||||||||||:||:|||:.|:|:|||
Human    26 ISYSLFTALRVWGVGNEAGVGP----------GLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLI 80

  Fly    83 SRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEYF 147
            |||.:||:.|:.||.:|:.||.|.|.||| ..::|||||:....||.:|:||||||:||.:||||
Human    81 SRSKDKLDQVSSEIKEKFKVETRTIAVDF-ASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYF 144

  Fly   148 LDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAF 212
            ||....| ..::.::..||.||..||.|.||||:.:.:|.|:|:||.:|::|.|||::||:||.|
Human   145 LDVPDLD-NVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTF 208

  Fly   213 VNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYL 277
            |:.||..|..||:..|:.:|||.|.||||.::||||.::..|||||:|:||:.|:|:.::|.|||
Human   209 VDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYL 273

  Fly   278 PHALL-QLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAK 319
            .|||: .::.:....::     ..|||.....||...|::..|
Human   274 IHALMGSIISNLPSWIY-----LKIVMNMNKSTRAHYLKKTKK 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	126/236 (53%)
HSD17B12	NP_057226.1	17beta-HSD1_like_SDR_c	50..289	CDD:187614	126/240 (53%)
		Di-lysine motif	308..312		1/4 (25%)