Protein Alignment spidey and HSD17B13

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_835236.2
• Gene: HSD17B13 / 345275
• HGNCID: 18685
• Length: 300
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 80/281 - (28%)
• Similarity: 115/281 - (40%)
• Gaps: 38/281 - (13%)

  Fly    49 SKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTG 113
            |..||..::||:..|||:....|.|:|...|||...:...:...|.|. .|.||......||.:.
Human    33 SVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAEC-RKLGVTAHAYVVDCSN 96

  Fly   114 GDEIYDKIRE--KTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTALF 176
            .:|||..:.:  |..| :|.::|||.|..|.     .|........:......||.....:|...
Human    97 REEIYRSLNQVKKEVG-DVTIVVNNAGTVYP-----ADLLSTKDEEITKTFEVNILGHFWITKAL 155

  Fly   177 LPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYK---EHGILIQSVQPGF 238
            ||.|:.:..|.|:.|:|..|....|.|..|.|:|.....|...|.:|.:   :.||....:.|.|
Human   156 LPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVF 220

  Fly   239 VATNMSKIRKASVFAPSPET--YVRSAL-------------STLGIATQTAGYLPH---ALLQLV 285
            |.|..:|.....:: |..||  .|||.:             |.:.|..:...:||.   |:|..:
Human   221 VNTGFTKNPSTRLW-PVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRM 284

  Fly   286 --IHFTEAVFGEQFARNIVMK 304
              |.| |||.|.:    |.||
Human   285 QNIQF-EAVVGHK----IKMK 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	71/260 (27%)
HSD17B13	NP_835236.2	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	66/246 (27%)