Protein Alignment spidey and HSD11B2

DIOPT Version :10

• Sequence 1: NP_572420.1
• Gene: spidey / 31703
• FlyBaseID: FBgn0029975
• Length: 321
• Species: Drosophila melanogaster
• Sequence 2: NP_000187.3
• Gene: HSD11B2 / 3291
• HGNCID: 5209
• Length: 405
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 68/276 - (24%)
• Similarity: 114/276 - (41%)
• Gaps: 39/276 - (14%)

  Fly    11 LLGGLAIGIVGFQVFRKVLPWIYANVVGP----KVFGSS--VDLSKMG---------EWAVVTGS 60
            ||..||:        ...|.|:...::.|    .|..::  :.||::.         ...::||.
Human    34 LLAALAL--------LAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGC 90

  Fly    61 TDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFT-GGD--EIYDKIR 122
            ..|.||..||:|...|  ..:::..||..:..|.|:.......:|::.:|.| .||  .:.:..:
Human    91 DSGFGKETAKKLDSMG--FTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTK 153

  Fly   123 EKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGV 187
            ..||...:..||||.    ||.|...|...:.....|:.:..|......:|...|| ::...||.
Human   154 AHTTSTGLWGLVNNA----GHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLP-LLRSSRGR 213

  Fly   188 IINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPG-FVATNMSKI----- 246
            |:.|.|.||.:|.|.|..|.::||.|....|....|....|:.:..:||| |...::..:
Human   214 IVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEK 278

  Fly   247 RKASVFAPSPETYVRS 262
            ||..:.|..|:..:::
Human   279 RKQLLLANLPQELLQA 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	58/229 (25%)
HSD11B2	NP_000187.3	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	58/219 (26%)
		Essential for protein stability	335..339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..405