DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spidey and hsd17b12a

DIOPT Version :9

Sequence 1:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_957175.1	Gene:	hsd17b12a / 327417	ZFINID:	ZDB-GENE-030131-5628	Length:	319	Species:	Danio rerio

Alignment Length:	266	Identity:	135/266 - (50%)
Similarity:	182/266 - (68%)	Gaps:	20/266 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IVGFQVFRKVLPWIYAN--VVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVL 81
            |.||::      |:..|  ::.|          |:|:||||||:||||||:||:||||||..::|
Zfish    37 ITGFRI------WVLGNGDLLSP----------KLGKWAVVTGATDGIGKSYAEELARRGFSMML 85

  Fly    82 ISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYGHPEY 146
            ||||.|||:.|||.:...|.||.:.|.|||:..| :|.||.:...||.:|:|||||||||.:||:
Zfish    86 ISRSQEKLDDVAKSLESTYKVETKTIAVDFSQID-VYPKIEKGLAGLEIGILVNNVGISYSYPEF 149

  Fly   147 FLDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKA 211
            ||.....: .|:..::..||.||..||.|.||.|.::.:|||:|:||.:|:.|.|||::||||||
Zfish   150 FLHIPDLE-NFITTMINVNITSVCQMTRLVLPRMEARAKGVILNISSASGMFPVPLLTIYSSTKA 213

  Fly   212 FVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGY 276
            ||:.||..||||||..||:||||.|.||||.|:||||.::..|:||.||.:.|:|:|:..||.||
Zfish   214 FVDFFSRGLQTEYKCKGIIIQSVLPFFVATKMTKIRKPTLDKPTPERYVAAELNTVGLQDQTNGY 278

  Fly   277 LPHALL 282
            .|||::
Zfish   279 FPHAVM 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	135/266 (51%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	128/231 (55%)
hsd17b12a	NP_957175.1	PLN02780	18..310	CDD:166421	135/266 (51%)
hsd17b12a	NP_957175.1	17beta-HSD1_like_SDR_c	56..288	CDD:187614	128/231 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H95094
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3104
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		otm25759
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	1	1.100	-	-	LDO	PTHR43899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R721
SonicParanoid	1	1.000	-	-		X484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870