DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spidey and hsd17b12b

DIOPT Version :9

Sequence 1:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_955907.1	Gene:	hsd17b12b / 322626	ZFINID:	ZDB-GENE-030131-1346	Length:	311	Species:	Danio rerio

Alignment Length:	311	Identity:	147/311 - (47%)
Similarity:	199/311 - (63%)	Gaps:	25/311 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SQVLSLLGGLAIGIVGFQVFRKVLPWIYANVVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAK 70
            |.:.||:.|:.:             ||..|       |:.:..|.:|:||||||:|||||||||:
Zfish    22 SSLWSLINGIRV-------------WILGN-------GNLMRASSLGKWAVVTGATDGIGKAYAE 66

  Fly    71 ELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVN 135
            ||||||..:|||||:.|||:.|:|.|..||.||.:.|..|| |..:||.||.....||.:|||||
Zfish    67 ELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADF-GSVDIYPKIESGLAGLEIGVLVN 130

  Fly   136 NVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPN 200
            |||:||.:||:||:....| .|:.|::..||.||..||.|.||.|:.:.:|||:||:|.:|:.|.
Zfish   131 NVGVSYSYPEFFLNIPDVD-SFINNMININIMSVCQMTRLVLPRMVDRSKGVILNVASASGMYPV 194

  Fly   201 PLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALS 265
            |||::||||||||:.||..|..|||..||:||||.|.:|.|.:|||||.::..|:||.||::.||
Zfish   195 PLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKIRKPTLDIPTPERYVKAQLS 259

  Fly   266 TLGIATQTAGYLPHALLQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRR 316
            |:|:.||:.||||||::..|   |.::...:.....||...|..|.|.|::
Zfish   260 TIGLQTQSNGYLPHAIMGWV---TASLLPAKLLNKYVMGMGLSQRARYLKK 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	146/309 (47%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	131/235 (56%)
hsd17b12b	NP_955907.1	PLN02780	8..307	CDD:166421	147/309 (48%)
hsd17b12b	NP_955907.1	17beta-HSD1_like_SDR_c	48..285	CDD:187614	132/241 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H95094
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3104
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		otm25759
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	1	1.100	-	-	O	PTHR43899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R721
SonicParanoid	1	1.000	-	-		X484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870