DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spidey and let-767

DIOPT Version :9

Sequence 1:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001293606.1	Gene:	let-767 / 175895	WormBaseID:	WBGene00002891	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	319	Identity:	123/319 - (38%)
Similarity:	187/319 - (58%)	Gaps:	24/319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GGLAIGIVGFQVFRKVLPWIYANVVGPKVFGSSVDLSKM--GEWAVVTGSTDGIGKAYAKELARR 75
            |.:|:..|.:::..     |::|::||.|..|.:||.|.  ..||||||:|||||||||.|||||
Worm    28 GYVALAAVAYRLLT-----IFSNILGPYVLLSPIDLKKRAGASWAVVTGATDGIGKAYAFELARR 87

  Fly    76 GLKLVLISRSLEKLNVVAKEIGDKY-GVEVRVIDVDFT-GGDEIYDKIREKTTGLNVGVLVNNVG 138
            |..::|:||:..||:...|||.:|| .:|||....||| .....|..:......:.:|||:||||
Worm    88 GFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTNAAPSAYKDLLATLNQVEIGVLINNVG 152

  Fly   139 ISYGHPEYFLDCYKADPPF--LRNIVAANIHS----VTHMTALFLPGMISQRRGVIINVSSTAGV 197
            :||.:|:..   :|.|...  |.||...|...    :|.::|..||.|::::.|||:||.|:||.
Worm   153 MSYEYPDVL---HKVDGGIERLANITTINTLPPTLFLTQLSAGILPQMVARKAGVIVNVGSSAGA 214

  Fly   198 IPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRS 262
            ....|.:|||:||.:|:..:..|:.||:..||.:|::.|..|||.|||:::.|.|.|....:.:|
Worm   215 NQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTIAPMMVATKMSKVKRTSFFTPDGAVFAKS 279

  Fly   263 ALSTLGIATQTAGYLPHALLQLVIHFTEAVFGEQFARNIVMKNI-LGTRKRALRRLAKE 320
            ||:|:|..:.|.||:.|   ||.:...:.:  ..|.|:.::.|: :|||..|||:..:|
Worm   280 ALNTVGNTSDTTGYITH---QLQLELMDLI--PTFIRDKILTNMSVGTRAAALRKKERE 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	123/319 (39%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	101/243 (42%)
let-767	NP_001293606.1	17beta-HSD1_like_SDR_c	64..310	CDD:187614	101/253 (40%)
let-767	NP_001293606.1	adh_short	66..265	CDD:278532	87/201 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167858
Domainoid	1	1.000	148	1.000	Domainoid score	I2740
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H95094
Inparanoid	1	1.050	201	1.000	Inparanoid score	I2462
Isobase	1	0.950	-	0.803099	Normalized mean entropy	S1433
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		mtm4736
orthoMCL	1	0.900	-	-		OOG6_100431
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R721
SonicParanoid	1	1.000	-	-		X484
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.790