DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spidey and hsd17b3

DIOPT Version :9

Sequence 1:	NP_572420.1	Gene:	spidey / 31703	FlyBaseID:	FBgn0029975	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	XP_012827001.1	Gene:	hsd17b3 / 101730254	XenbaseID:	XB-GENE-986068	Length:	302	Species:	Xenopus tropicalis

Alignment Length:	289	Identity:	116/289 - (40%)
Similarity:	162/289 - (56%)	Gaps:	30/289 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FQVFRKVLPWIYANVVGPKVFGSSVDLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSL 86
            ||..|.|||..:              ...:||||||||:.|||||||:.|||.||:.:|:|||:|
Frog    28 FQHLRGVLPQSF--------------FQSLGEWAVVTGAGDGIGKAYSTELANRGMNIVMISRTL 78

  Fly    87 EKLNVVAKEIGDKYGVEVRVIDVDFTGGDEIYDKIREKTTGLNVGVLVNNVGISYG-HPEYFLDC 150
            ||:..||.:|....|..|::|..||| .|.||:.|.|...||.:|:|:||||:.:. .|..||
Frog    79 EKMQAVAMDIEQSTGKNVKIIQADFT-KDNIYEHIEEGLKGLKIGILINNVGMLHNPDPCRFL-- 140

  Fly   151 YKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNK 215
              :.|...:|::..||.|...||.:.|..|..::.|:|:|:||..|..|.||.:|||::||||..
Frog   141 --SGPDNDKNVINCNITSTIKMTRIILKQMEKRKSGLILNISSAVGRFPCPLYAVYSASKAFVTT 203

  Fly   216 FSDDLQTEYKEHGILIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLGIATQTAGYLPHA 280
            ||..||.|||..||:||:|.|..|:|.|::..:.:.....|..:||.:|:.:.|..:|.|...||
Frog   204 FSKALQAEYKSKGIIIQAVTPYGVSTPMTRNARTNAITKRPVDFVRQSLNCVTIGDETFGCFAHA 268

  Fly   281 LLQL--------VIHFT--EAVFGEQFAR 299
            :|..        |||.|  :..|..:|.|
Frog   269 VLGCIMDCIPLWVIHSTAVQEKFLHRFNR 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spidey	NP_572420.1	PLN02780	8..321	CDD:166421	116/289 (40%)
spidey	NP_572420.1	17beta-HSD1_like_SDR_c	52..288	CDD:187614	105/244 (43%)
hsd17b3	XP_012827001.1	17beta-HSD1_like_SDR_c	44..281	CDD:187614	103/241 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R721
SonicParanoid	1	1.000	-	-		X484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.050