DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr14 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001245573.1	Gene:	dpr14 / 31702	FlyBaseID:	FBgn0029974	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	290	Identity:	54/290 - (18%)
Similarity:	93/290 - (32%)	Gaps:	63/290 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EELEVTETTTHEPFPFFADPY--------------TTLNI-------------STQLSSSVYLHC 96
            |:...:...|:..:.||.:|.              |.:|:             :|.:.|.|.|.|
Human   265 EDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTC 329

  Fly    97 RVNDLQGKTVSWMRRRGDDLTLITFGQHTYSGDSRYSLEFEE-PNDWKLLIQFANERDEGPYECQ 160
            ........|::|.::..:      .|..........:|..:. .|..:||::...:.|.|.|.|:
Human   330 VWVGNPPLTLTWTKKDSN------MGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCR 388

  Fly   161 VSSHPPLVLLVYLTIIVPHVEILDERG----------SATPEKYYKAGSTIELQCVISKIPHPSS 215
            .              |||.:.:.:...          |:...:|...|...:::|.|...| |..
Human   389 A--------------IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTP-PPD 438

  Fly   216 YITWRHGPRLLNYDTSRGGISVKTDMLPGRALSRLYIANANRQD-TGNYTCMLGNEITETVVVHV 279
            .|.|......|...|.......:|:...| .||.|.|.|....| ..:|.|...|.......:..
Human   439 RIAWAWKENFLEVGTLERYTVERTNSGSG-VLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQ 502

  Fly   280 LNGEEPAAMQHANGSRQKANASTMVVLFLV 309
            |...|...:....|:  ...||.:::.|.:
Human   503 LEEREVLPVGIIAGA--TIGASILLIFFFI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr14	NP_001245573.1	IG_like	83..163	CDD:214653	17/93 (18%)
		Ig	84..169	CDD:299845	16/98 (16%)
		IG_like	191..279	CDD:214653	21/88 (24%)
		Ig	201..274	CDD:143165	19/73 (26%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236
		I-set	223..304	CDD:254352	6/38 (16%)
		Ig_2	227..305	CDD:290606	7/39 (18%)
		Ig_2	311..405	CDD:290606	19/113 (17%)
		IG_like	314..405	CDD:214653	19/110 (17%)
		Ig5_KIRREL3	407..504	CDD:143306	22/98 (22%)
		IG_like	416..504	CDD:214653	21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810