DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr14 and itgb4

DIOPT Version :9

Sequence 1:	NP_001245573.1	Gene:	dpr14 / 31702	FlyBaseID:	FBgn0029974	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	291	Identity:	59/291 - (20%)
Similarity:	105/291 - (36%)	Gaps:	68/291 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GDPFDTFPKNFWQEFSSPFTDTPEDEELEVTETTTHEPFPFFADPYTTLNISTQLSSSVYLHCRV 98
            ||..|.:...|     ..|.|...:.:.::......||:.....|::..|: .:|:|::....:
Zfish   159 GDLSDDYTIGF-----GKFVDKVTEPQTDMRPAKLAEPWSNSDPPFSFRNV-IKLTSNITSFRQ- 216

  Fly    99 NDLQGKTVS------------------------WMRRRGDDLTLITFGQHTYSGDSRYSLEFEEP 139
             .||.:.:|                        |   |.|...|:.|     |.:|.:..|.:..
Zfish   217 -KLQKERISGNLDAPEGGFDAILQTAVCQDQIGW---RKDSTHLLVF-----STESAFHYEADGA 272

  Fly   140 NDWKLLIQFANERDE-------GPYECQV-SSHPPLVLLVYLTI---IVPHVEILDERGSATPEK 193
            |   :|....:..||       |.|...| ..:|.:..||.|.:   |:|...:.:...|.. ||
Zfish   273 N---VLAGILDRNDEQCHLNVDGNYTHDVRQDYPSIPTLVRLLVKHNIIPIFAVTNHSYSYY-EK 333

  Fly   194 YYKAGSTIELQCVISKIPHPSSYITWRHGPRLLN--YDTSRGGISVKTDMLPGRALSRLYIANAN 256
            .::.....||    .::...||.|.     .:|.  ::..|..||::.:..|....::::..:..
Zfish   334 LHEYFPIAEL----GQLQEDSSNIL-----SILEKAFENIRSKISIRAEDRPKAVETKIFSQSGT 389

  Fly   257 RQDTGNYTCMLGNEITETVVVHVLN--GEEP 285
            ..:.||:....|......|.:..||  ||||
Zfish   390 FSEYGNFKITPGQTGKFKVRMKALNQVGEEP 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr14	NP_001245573.1	IG_like	83..163	CDD:214653	21/111 (19%)
		Ig	84..169	CDD:299845	21/116 (18%)
		IG_like	191..279	CDD:214653	16/89 (18%)
		Ig	201..274	CDD:143165	13/74 (18%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776	59/291 (20%)
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900