DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr14 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001245573.1	Gene:	dpr14 / 31702	FlyBaseID:	FBgn0029974	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	219	Identity:	50/219 - (22%)
Similarity:	85/219 - (38%)	Gaps:	64/219 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EPFPFFADPYTTLNISTQLSSSVYLHCRVNDLQGKTVSWMRRRGDDLTLITFGQHTYSGDSRYSL 134
            ||..|..:|  ..:|:.::...|.:.||...:...:::|.:    |..|:..|:.|
Mouse   310 EPPQFVREP--ERHITAEMEKVVDIPCRAKGVPPPSITWYK----DAALVEVGKLT--------- 359

  Fly   135 EFEEPNDWKLLIQFANERDEGPYEC---------QVSSHPPLVLLVYLTIIVPHV-------EIL 183
            .|::.:|..|.|......|.|..:|         |.|::      :.:|.|.|::       .::
Mouse   360 RFKQRSDGGLQISGLLPDDTGMLQCFAHNAAGEAQTSTY------LAVTSIAPNITRGPLDSTVI 418

  Fly   184 DERGSATPEKYYKAGSTIELQCVISKIPHPSSYITWRHGPRLLNYDTSRGGISVKTDMLPGRAL- 247
            |             |.::.|.|..|..|.|:  |||:.|.|:|    :.|.:     .||...|
Mouse   419 D-------------GMSVVLACETSGAPRPA--ITWQKGERIL----ASGSV-----QLPRFTLL 459

  Fly   248 --SRLYIANANRQDTGNYTCMLGN 269
              ..|.|:..:..|.|.|||:..|
Mouse   460 ESGSLLISPTHISDAGTYTCLATN 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr14	NP_001245573.1	IG_like	83..163	CDD:214653	17/88 (19%)
		Ig	84..169	CDD:299845	18/93 (19%)
		IG_like	191..279	CDD:214653	24/82 (29%)
		Ig	201..274	CDD:143165	23/72 (32%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653
		Ig	136..192	CDD:299845
		IG_like	226..308	CDD:214653
		IGc2	237..290	CDD:197706
		I-set	312..401	CDD:254352	20/109 (18%)
		Ig	330..398	CDD:143165	17/80 (21%)
		I-set	406..496	CDD:254352	26/102 (25%)
		Ig	420..496	CDD:299845	24/75 (32%)
		Ig	506..590	CDD:299845
		IG_like	506..590	CDD:214653
		FN3	594..685	CDD:238020
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810