DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr14 and CADM4

DIOPT Version :9

Sequence 1:NP_001245573.1 Gene:dpr14 / 31702 FlyBaseID:FBgn0029974 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_660339.1 Gene:CADM4 / 199731 HGNCID:30825 Length:388 Species:Homo sapiens


Alignment Length:349 Identity:67/349 - (19%)
Similarity:106/349 - (30%) Gaps:128/349 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 TLNISTQLSSSVYLHCRVNDLQGKTVSWMRRRGDDLTLITFGQHTYSGDSRYSLEFEEPNDWKLL 145
            |.|::........:.||::...|..|  :.:.....||...|..... |.|:.||...|...::.
Human    29 TENVTVAEGGVAEITCRLHQYDGSIV--VIQNPARQTLFFNGTRALK-DERFQLEEFSPRRVRIR 90

  Fly   146 IQFANERDEGPYECQVSSHPPLVLLVYLTIIV----PHVEILDE----------------RGSAT 190
            :..|...|||.|.||:.:......:..||::|    |.||:.::                |.:||
Human    91 LSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAT 155

  Fly   191 PEKY------------------------------------------------------------- 194
            ...|                                                             
Human   156 LRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDV 220

  Fly   195 --------------YKAGSTIELQCVISKIPHPSSYITWRHGPRLLNYDTSRGGISVKTDMLPGR 245
                          .:.|.|:.|.|.::..|.|:. |.|..|...|   ..|.....:|..||| 
Human   221 QYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQ-IRWNRGNESL---PERAEAVGETLTLPG- 280

  Fly   246 ALSRLYIANANRQDTGNYTCMLGNEITETVVVHVLNGEEPAAMQHANGSRQKANASTMVVL--FL 308
                  :.:|   |.|.|||...|:......::||...:|.|:..|..|...|....::.|  ||
Human   281 ------LVSA---DNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFL 336

  Fly   309 VYVCISGSISVAGMNRGLGLGQVW 332
            : :|:.             :|.||
Human   337 I-ICVL-------------VGMVW 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr14NP_001245573.1 IG_like 83..163 CDD:214653 20/79 (25%)
Ig 84..169 CDD:299845 19/84 (23%)
IG_like 191..279 CDD:214653 23/162 (14%)
Ig 201..274 CDD:143165 20/72 (28%)
CADM4NP_660339.1 Ig 29..120 CDD:416386 22/93 (24%)
FR1 29..45 CDD:409353 2/15 (13%)
Ig strand A' 30..36 CDD:409353 1/5 (20%)
Ig strand B 38..46 CDD:409353 1/7 (14%)
CDR1 46..51 CDD:409353 0/4 (0%)
FR2 52..59 CDD:409353 1/8 (13%)
Ig strand C 52..58 CDD:409353 1/7 (14%)
CDR2 60..71 CDD:409353 3/10 (30%)
Ig strand C' 62..66 CDD:409353 2/3 (67%)
Ig strand C' 68..71 CDD:409353 1/2 (50%)
FR3 72..107 CDD:409353 12/35 (34%)
Ig strand D 76..83 CDD:409353 3/6 (50%)
Ig strand E 86..92 CDD:409353 0/5 (0%)
Ig strand F 99..107 CDD:409353 5/7 (71%)
CDR3 108..111 CDD:409353 0/2 (0%)
Ig strand G 111..120 CDD:409353 1/8 (13%)
FR4 113..120 CDD:409353 1/6 (17%)
IgI_2_Necl-4 121..220 CDD:409468 8/98 (8%)
Ig strand B 141..145 CDD:409468 0/3 (0%)
Ig strand C 155..159 CDD:409468 1/3 (33%)
Ig strand E 182..186 CDD:409468 0/3 (0%)
Ig strand F 196..201 CDD:409468 0/4 (0%)
Ig strand G 213..216 CDD:409468 0/2 (0%)
Ig_3 224..295 CDD:404760 21/84 (25%)
Ig strand A' 231..235 CDD:409353 0/3 (0%)
Ig strand B 241..248 CDD:409353 2/6 (33%)
Ig strand C 255..260 CDD:409353 2/5 (40%)
Ig strand C' 262..264 CDD:409353 0/1 (0%)
Ig strand E 274..280 CDD:409353 2/5 (40%)
Ig strand F 287..294 CDD:409353 4/6 (67%)
Ig strand G 300..308 CDD:409353 2/7 (29%)
4.1m 344..362 CDD:128590 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 79 1.000 Inparanoid score I5236
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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