DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bys and ENP1

DIOPT Version :9

Sequence 1:	NP_511074.1	Gene:	bys / 31701	FlyBaseID:	FBgn0010292	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_009806.3	Gene:	ENP1 / 852549	SGDID:	S000000451	Length:	483	Species:	Saccharomyces cerevisiae

Alignment Length:	478	Identity:	172/478 - (35%)
Similarity:	265/478 - (55%)	Gaps:	79/478 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KPKKANVATIKNVNLEKQITEGRVAKN--KNKDKVKLRAEESANIDARSSQKILAAAKLQQLELD 65
            |...|...|:|.:|.:|      :|:|  .|.|...   ||...||:::|:|||..||.||.|::
Yeast    19 KDLDAAQGTLKKINKKK------LAQNDAANHDAAN---EEDGYIDSKASRKILQLAKEQQDEIE 74

  Fly    66 EENFPSLVTVKK-----VNFSLND----------------------GHVKEDEEVNETDLMADLD 103
            .|........|:     ...|.:|                      |..||:||:        ::
Yeast    75 GEELAESERNKQFEARFTTMSYDDEDEDEDEDEEAFGEDISDFEPEGDYKEEEEI--------VE 131

  Fly   104 MDEDDVAAFERFQQPAQEGKR---TLHLSKMIMQKIQEKEADIHTKISDE--------------G 151
            :||:|.|.||::.:.:.:...   :.:|:..||..|:|||:.:.....||              .
Yeast   132 IDEEDAAMFEQYFKKSDDFNSLSGSYNLADKIMASIREKESQVEDMQDDEPLANEQNTSRGNISS 196

  Fly   152 SLKIEE---IDPKVKEMYEGVRDVLKRYRSGKIPKAFKIIPKLRNWEQILFITEPHNWSAAAMFQ 213
            .||..|   :..||.:.|..|..:||.:..||:||.||:||.||||:.::::|.|..||...:::
Yeast   197 GLKSGEGVALPEKVIKAYTTVGSILKTWTHGKLPKLFKVIPSLRNWQDVIYVTNPEEWSPHVVYE 261

  Fly   214 GTRIFCSVLSQAMAQRFYNLVLLPRVRDDL--CEYKKLNMHLYNALKRALFKPAAFMKGIILPLL 276
            .|::|.|.|:...:|:|.||:||.|.||::  .|...||.|:|.|:|::|:||:||.||.:.||:
Yeast   262 ATKLFVSNLTAKESQKFINLILLERFRDNIETSEDHSLNYHIYRAVKKSLYKPSAFFKGFLFPLV 326

  Fly   277 EGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYSGANSIFIRYFLDKRYALPYRVVDAA 341
            |.| |.:|||.|.|||:|:.|:|.|||||.|..:..:.:|...::||:..|||:|||||:.||..
Yeast   327 ETG-CNVREATIAGSVLAKVSVPALHSSAALSYLLRLPFSPPTTVFIKILLDKKYALPYQTVDDC 390

  Fly   342 VFHFLRF---------ENDKRELPVLWHQSLLTFAQRYKNDISSEQRDALLQLLKKKSHFKITPD 397
            |::|:||         |:..|.|||:||::.|||||||||||:.:|||.||:.::::.|..|.|:
Yeast   391 VYYFMRFRILDDGSNGEDATRVLPVIWHKAFLTFAQRYKNDITQDQRDFLLETVRQRGHKDIGPE 455

  Fly   398 VRRELQAASCRD-VEMMETDNGL 419
            :||||.|.:.|: |:..|.::.|
Yeast   456 IRRELLAGASREFVDPQEANDDL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bys	NP_511074.1	Bystin	128..412	CDD:283057	132/312 (42%)
ENP1	NP_009806.3	Bystin	156..470	CDD:398790	131/314 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343638
Domainoid	1	1.000	252	1.000	Domainoid score	I333
eggNOG	1	0.900	-	-		E1_KOG3871
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2991
Inparanoid	1	1.050	279	1.000	Inparanoid score	I565
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53886
OrthoFinder	1	1.000	-	-		FOG0005208
OrthoInspector	1	1.000	-	-		oto99823
orthoMCL	1	0.900	-	-		OOG6_102261
Panther	1	1.100	-	-	LDO	PTHR12821
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1724
SonicParanoid	1	1.000	-	-		X3721
TreeFam	1	0.960	-	-
	15	14.790