DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bys and BYSL

DIOPT Version :9

Sequence 1:	NP_511074.1	Gene:	bys / 31701	FlyBaseID:	FBgn0010292	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_004044.3	Gene:	BYSL / 705	HGNCID:	1157	Length:	437	Species:	Homo sapiens

Alignment Length:	419	Identity:	218/419 - (52%)
Similarity:	288/419 - (68%)	Gaps:	23/419 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KNVNLEKQITEGRVAKNKNKDKVKLR----AEESANIDARSSQKILAAAKLQQLELDEEN----- 68
            |:..|..||..|...:...::|.:.|    |||. .:..|.|::||..|:.||.||:.|:
Human    15 KHAPLADQILAGNAVRAGVREKRRGRGTGEAEEE-YVGPRLSRRILQQARQQQEELEAEHGTGDK 78

  Fly    69 --FPSLVTVKKVNFSLNDGHVKEDEE---VNETDLM------ADLDMDEDDVAAFERFQQPAQEG 122
              .|...|.:.......||...||||   :.:...|      |::.:|.:|..|.|.|.......
Human    79 PAAPRERTTRLGPRMPQDGSDDEDEEWPTLEKAATMTAAGHHAEVVVDPEDERAIEMFMNKNPPA 143

  Fly   123 KRTLHLSKMIMQKIQEKEADIHTKISDEGSLKIEEIDPKVKEMYEGVRDVLKRYRSGKIPKAFKI 187
            :||  |:.:||:|:.||:.::.|.:|:.....:.::||:|.|:|.|||:||.:|||||:||||||
Human   144 RRT--LADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLSKYRSGKLPKAFKI 206

  Fly   188 IPKLRNWEQILFITEPHNWSAAAMFQGTRIFCSVLSQAMAQRFYNLVLLPRVRDDLCEYKKLNMH 252
            ||.|.||||||::|||..|:||||:|.||||.|.|.:.|||||||||||||||||:.|||:||.|
Human   207 IPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDVAEYKRLNFH 271

  Fly   253 LYNALKRALFKPAAFMKGIILPLLEGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYSG 317
            ||.|||:|||||.|:.|||::||.|.|.||||||||.||::.:.|||||||||.:|||.||.|||
Human   272 LYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSG 336

  Fly   318 ANSIFIRYFLDKRYALPYRVVDAAVFHFLRFENDKRELPVLWHQSLLTFAQRYKNDISSEQRDAL 382
            |||||:|..|||:|||||||:||.|||||.|..:||||||||||.|||..||||.|::::|::||
Human   337 ANSIFLRLLLDKKYALPYRVLDALVFHFLGFRTEKRELPVLWHQCLLTLVQRYKADLATDQKEAL 401

  Fly   383 LQLLKKKSHFKITPDVRRELQAASCRDVE 411
            |:||:.:.|.:::|::|||||:|..||||
Human   402 LELLRLQPHPQLSPEIRRELQSAVPRDVE 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bys	NP_511074.1	Bystin	128..412	CDD:283057	181/284 (64%)
BYSL	NP_004044.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		27/90 (30%)
BYSL	NP_004044.3	Bystin	144..431	CDD:398790	183/289 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146867
Domainoid	1	1.000	384	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_KOG3871
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2991
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1914
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53886
OrthoDB	1	1.010	-	-		D1193442at2759
OrthoFinder	1	1.000	-	-		FOG0005208
OrthoInspector	1	1.000	-	-		oto90452
orthoMCL	1	0.900	-	-		OOG6_102261
Panther	1	1.100	-	-	LDO	PTHR12821
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1724
SonicParanoid	1	1.000	-	-		X3721
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800