DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bys and Bysl

DIOPT Version :9

Sequence 1:	NP_511074.1	Gene:	bys / 31701	FlyBaseID:	FBgn0010292	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_058555.3	Gene:	Bysl / 53414	MGIID:	1858419	Length:	436	Species:	Mus musculus

Alignment Length:	425	Identity:	218/425 - (51%)
Similarity:	293/425 - (68%)	Gaps:	24/425 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KNVNLEKQITEGRVAKNKNKDKVKLR--AEESANIDARSSQKILAAAKLQQLELD------EENF 69
            |:..|.:||..|...:...::|.:.|  .||...:..|.|::||..|:.||.||:      :.:.
Mouse    15 KHAPLAEQILAGNAVRAGTREKRRGREVEEEEEYVGPRLSRRILQQARQQQEELETDHGAGDRSA 79

  Fly    70 PSLVTVKKVNFSL-NDGHVKEDEE---------VNETDLMADLDMDEDDVAAFERFQQPAQEGKR 124
            |......::...| .||..:||||         :...|..|::.:|.:|..|.|.|.......:|
Mouse    80 PPRERATRLGPGLPQDGSDEEDEEWPTLEKAAKMAGVDHQAEVIVDPEDERAIEMFMNKNPPVRR 144

  Fly   125 TLHLSKMIMQKIQEKEADIHTKISDEGSLKIEEIDPKVKEMYEGVRDVLKRYRSGKIPKAFKIIP 189
            |  |:.:||:|:.||:.::.|.:|:.....:.::||:|.|:|.|||:||.:|||||:|||||:||
Mouse   145 T--LADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGKLPKAFKVIP 207

  Fly   190 KLRNWEQILFITEPHNWSAAAMFQGTRIFCSVLSQAMAQRFYNLVLLPRVRDDLCEYKKLNMHLY 254
            .|.||||||::|||..|:||||:|.||||.|.|.:.|||||||||||||||||:.|||:||.|||
Mouse   208 ALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNFHLY 272

  Fly   255 NALKRALFKPAAFMKGIILPLLEGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYSGAN 319
            .|||:|||||.|:.|||::||.|.|.||||||||.||::.:.|||||||||.:|||.||.|||||
Mouse   273 MALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIITKCSIPVLHSSAAMLKIAEMEYSGAN 337

  Fly   320 SIFIRYFLDKRYALPYRVVDAAVFHFLRFENDKRELPVLWHQSLLTFAQRYKNDISSEQRDALLQ 384
            |||:|..|||:|||||||:||.|||||.|..:||:|||||||.|||.|||||.|:::||::|||:
Mouse   338 SIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEALLE 402

  Fly   385 LLKKKSHFKITPDVRRELQAASCRDVEMMETDNGL 419
            ||:.:.|.:::|::|||||:|..||||    |.|:
Mouse   403 LLRLQPHPQLSPEIRRELQSAVPRDVE----DGGV 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bys	NP_511074.1	Bystin	128..412	CDD:283057	180/283 (64%)
Bysl	NP_058555.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		24/87 (28%)
Bysl	NP_058555.3	Bystin	143..430	CDD:283057	183/292 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836815
Domainoid	1	1.000	384	1.000	Domainoid score	I817
eggNOG	1	0.900	-	-		E1_KOG3871
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2991
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1849
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53886
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005208
OrthoInspector	1	1.000	-	-		oto94036
orthoMCL	1	0.900	-	-		OOG6_102261
Panther	1	1.100	-	-	LDO	PTHR12821
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1724
SonicParanoid	1	1.000	-	-		X3721
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790