DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bys and Bysl

DIOPT Version :9

Sequence 1:	NP_511074.1	Gene:	bys / 31701	FlyBaseID:	FBgn0010292	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_872615.3	Gene:	Bysl / 359727	RGDID:	727959	Length:	436	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	215/420 - (51%)
Similarity:	289/420 - (68%)	Gaps:	26/420 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KNVNLEKQITEGRVAKNKNKDKVKLRA--EESANIDARSSQKILAAAKLQQLELDEENF----PS 71
            ::..|.:||..|...:...::|.:...  ||...:..|.|::||..|:.||.||:.|:.    |:
  Rat    15 RHAPLAEQILAGDAVRAGTREKRRRHGVEEEEEYVGPRLSRRILQQARQQQEELETEHATGDRPA 79

  Fly    72 LVTVKKVNFS---LNDGHVKEDEE------------VNETDLMADLDMDEDDVAAFERFQQPAQE 121
            ....:.....   ..||..:||||            ||.   .|::.:|.:|..|.|.|......
  Rat    80 KPRERATRLGPGVPQDGSDEEDEEWPTLEKAAKMTVVNH---QAEVVVDPEDERAIEMFMNKNPP 141

  Fly   122 GKRTLHLSKMIMQKIQEKEADIHTKISDEGSLKIEEIDPKVKEMYEGVRDVLKRYRSGKIPKAFK 186
            .:||  |:.:||:|:.||:.::.|.:|:.....:.::||:|.|:|.|||:||.:|||||:|||||
  Rat   142 VRRT--LADIIMEKLTEKQTEVETVMSEVSGFPMPQLDPRVLEVYRGVREVLCKYRSGKLPKAFK 204

  Fly   187 IIPKLRNWEQILFITEPHNWSAAAMFQGTRIFCSVLSQAMAQRFYNLVLLPRVRDDLCEYKKLNM 251
            |||.|.||||||::|||..|:||||:|.||||.|.|.:.|||||||||||||||||:.|||:||.
  Rat   205 IIPALSNWEQILYVTEPEAWTAAAMYQATRIFASNLKERMAQRFYNLVLLPRVRDDIAEYKRLNF 269

  Fly   252 HLYNALKRALFKPAAFMKGIILPLLEGGDCTLREAIIFGSVVARSSIPVLHSSACLLKICEMAYS 316
            |||.|||:|||||.|:.|||::||.|.|.||||||||.||::::.|||||||||.:|||.||.||
  Rat   270 HLYMALKKALFKPGAWFKGILIPLCESGTCTLREAIIVGSIISKCSIPVLHSSAAMLKIAEMEYS 334

  Fly   317 GANSIFIRYFLDKRYALPYRVVDAAVFHFLRFENDKRELPVLWHQSLLTFAQRYKNDISSEQRDA 381
            ||:|||:|..|||:|||||||:||.|||||.|..:||:|||||||.|||.|||||.|:::||::|
  Rat   335 GASSIFLRLLLDKKYALPYRVLDALVFHFLAFRTEKRQLPVLWHQCLLTLAQRYKADLATEQKEA 399

  Fly   382 LLQLLKKKSHFKITPDVRRELQAASCRDVE 411
            ||:||:.:.|.:::|::|||||:|..||||
  Rat   400 LLELLRLQPHPQLSPEIRRELQSAVPRDVE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bys	NP_511074.1	Bystin	128..412	CDD:283057	181/284 (64%)
Bysl	NP_872615.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		24/89 (27%)
Bysl	NP_872615.3	Bystin	143..430	CDD:398790	183/289 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340522
Domainoid	1	1.000	380	1.000	Domainoid score	I810
eggNOG	1	0.900	-	-		E1_KOG3871
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2991
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1871
OMA	1	1.010	-	-		QHG53886
OrthoDB	1	1.010	-	-		D1193442at2759
OrthoFinder	1	1.000	-	-		FOG0005208
OrthoInspector	1	1.000	-	-		oto97562
orthoMCL	1	0.900	-	-		OOG6_102261
Panther	1	1.100	-	-	LDO	PTHR12821
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3721
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810