DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpS6 and rps6

DIOPT Version :9

Sequence 1:	NP_511073.1	Gene:	RpS6 / 31700	FlyBaseID:	FBgn0261592	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_001003728.1	Gene:	rps6 / 445028	ZFINID:	ZDB-GENE-040801-8	Length:	249	Species:	Danio rerio

Alignment Length:	250	Identity:	186/250 - (74%)
Similarity:	216/250 - (86%)	Gaps:	3/250 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQ 65
            ||||:|:||||||||.||.||.|||:||||||...|.||.||||||||.:||:||||||||||||
Zfish     1 MKLNISFPATGCQKLIEVDDERKLRIFYEKRMATEVAADSLGDEWKGYVVRISGGNDKQGFPMKQ 65

  Fly    66 GVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIP 130
            ||||||||||||.|||||||||||||||||||||||||||:|||.||:::|||||||||||:|:|
Zfish    66 GVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVRKGEKDIPGLTDSTVP 130

  Fly   131 RRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIAL 195
            |||||||||:||||:|||||||||::|||||| .|:.||..:||||||||:||.|||.|.|||||
Zfish   131 RRLGPKRASRIRKLFNLSKEDDVRQYVVRRPL-TKEGKKPRTKAPKIQRLVTPRVLQHKRRRIAL 194

  Fly   196 KKKRQIASKEASADYAKLLVQRKKESKAKREE--AKRRRSASIRESKSSVSSDKK 248
            |::|.:.:|||:|:|.|||.:|.||:|.||:|  |||||.:|:|.|.|...|.:|
Zfish   195 KRQRTLKNKEAAAEYTKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpS6	NP_511073.1	Ribosomal_S6e	1..222	CDD:294602	171/220 (78%)
rps6	NP_001003728.1	Ribosomal_S6e	1..215	CDD:294602	168/214 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575816
Domainoid	1	1.000	224	1.000	Domainoid score	I2496
eggNOG	1	0.900	-	-		E1_COG2125
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H85949
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2077
OMA	1	1.010	-	-		QHG53585
OrthoDB	1	1.010	-	-		D1326714at2759
OrthoFinder	1	1.000	-	-		FOG0003187
OrthoInspector	1	1.000	-	-		oto38945
orthoMCL	1	0.900	-	-		OOG6_100737
Panther	1	1.100	-	-	LDO	PTHR11502
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1248
SonicParanoid	1	1.000	-	-		X2145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800