DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpS6 and Rps6

DIOPT Version :9

Sequence 1:	NP_511073.1	Gene:	RpS6 / 31700	FlyBaseID:	FBgn0261592	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_033122.1	Gene:	Rps6 / 20104	MGIID:	98159	Length:	249	Species:	Mus musculus

Alignment Length:	250	Identity:	187/250 - (74%)
Similarity:	214/250 - (85%)	Gaps:	3/250 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLNVSYPATGCQKLFEVVDEHKLRVFYEKRMGQVVEADILGDEWKGYQLRIAGGNDKQGFPMKQ 65
            ||||:|:||||||||.||.||.|||.||||||...|.||.||:|||||.:||:||||||||||||
Mouse     1 MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQ 65

  Fly    66 GVLTHGRVRLLLKKGHSCYRPRRTGERKRKSVRGCIVDANMSVLALVVLKKGEKDIPGLTDTTIP 130
            ||||||||||||.|||||||||||||||||||||||||||:|||.||::||||||||||||||:|
Mouse    66 GVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVP 130

  Fly   131 RRLGPKRASKIRKLYNLSKEDDVRRFVVRRPLPAKDNKKATSKAPKIQRLITPVVLQRKHRRIAL 195
            |||||||||:||||:|||||||||::|||:|| .|:.||..:||||||||:||.|||.|.|||||
Mouse   131 RRLGPKRASRIRKLFNLSKEDDVRQYVVRKPL-NKEGKKPRTKAPKIQRLVTPRVLQHKRRRIAL 194

  Fly   196 KKKRQIASKEASADYAKLLVQRKKESKAKREE--AKRRRSASIRESKSSVSSDKK 248
            ||:|...:||.:|:|||||.:|.||:|.||:|  |||||.:|:|.|.|...|.:|
Mouse   195 KKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpS6	NP_511073.1	Ribosomal_S6e	1..222	CDD:294602	172/220 (78%)
Rps6	NP_033122.1	Ribosomal_S6e	1..215	CDD:412654	169/214 (79%)
Rps6	NP_033122.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..249		16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833083
Domainoid	1	1.000	223	1.000	Domainoid score	I2573
eggNOG	1	0.900	-	-		E1_COG2125
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H85949
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2131
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53585
OrthoDB	1	1.010	-	-		D1326714at2759
OrthoFinder	1	1.000	-	-		FOG0003187
OrthoInspector	1	1.000	-	-		oto92571
orthoMCL	1	0.900	-	-		OOG6_100737
Panther	1	1.100	-	-	LDO	PTHR11502
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1248
SonicParanoid	1	1.000	-	-		X2145
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800